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THE ASSESSMENT OF POTENTIAL DRUG INTERACTIONS WITH A NEW TRICYCLIC ANTIDEPRESSANT DRUG
| Content Provider | Scilit |
|---|---|
| Author | Briant, R. H. George, C. F. |
| Copyright Year | 1974 |
| Description | Journal: British journal of clinical pharmacology 1 Methods for the investigation of possible interactions with tricyclic antidepressant drugs are described. These methods have been applied to a new compound, Ciba 34276-Ba, which has been shown to have antidepressant activity. 2 In five normal volunteers tested before and during treatment with Ciba 34276-Ba, no abnormalities of resting or post-exercise electrocardiographs occurred. A three-fold reduction in tyramine-responsiveness was seen in three normal subjects studied, but no potentiation of the noradrenaline pressor effect occurred. One of six patients given Ciba 34276-Ba whilst on long-term treatment with bethanidine showed loss of blood pressure control. 3 The metabolic clearance of antipyrine was unaltered in two subjects studied, showing no evidence of induction or inhibition of hepatic microsomal oxidizing enzymes by Ciba 34276-Ba. |
| Related Links | http://europepmc.org/articles/pmc1402449?pdf=render https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1402449/pdf https://onlinelibrary.wiley.com/doi/pdf/10.1111/j.1365-2125.1974.tb00219.x |
| Ending Page | 118 |
| Page Count | 6 |
| Starting Page | 113 |
| e-ISSN | 13652125 |
| DOI | 10.1111/j.1365-2125.1974.tb00219.x |
| Journal | British journal of clinical pharmacology |
| Issue Number | 2 |
| Volume Number | 1 |
| Language | English |
| Publisher | Wiley-Blackwell |
| Publisher Date | 1974-04-01 |
| Access Restriction | Open |
| Subject Keyword | Journal: British journal of clinical pharmacology Peripheral Vascular Disease Blood Pressure Antidepressant Drugs Tricyclic Antidepressant Subjects Studied |
| Content Type | Text |
| Resource Type | Article |
