NDLI: Antibiotic regimens for suspected early neonatal sepsis

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Antibiotic regimens for suspected early neonatal sepsis

Content Provider	Scilit
Author	Mtitimila, Edward I. Cooke, Richard Wi
Copyright Year	2004
Description	Journal: Cochrane Database of Systematic Reviews Early acquired infection may cause severe illness or death in the neonatal period. Prompt treatment with antibiotics has shown to reduce mortality. It is not clear which antibiotic regimen is suitable for treatment of presumed early neonatal sepsis. To compare effectiveness and adverse effects of antibiotic regimens for treatment of presumed early neonatal sepsis. The Cochrane Central Register of Controlled Trials (CENTRAL, The Cochrane Library, Issue 2, 2003), MEDLINE (1966 to August 2003), EMBASE (1980 to September 2003) and ZETOC (1993 to August 2003) databases were searched for possible studies. Pharmaceutical companies were contacted for any unpublished data. Randomised and quasi-randomised controlled studies comparing antibiotic regimens for the treatment of early neonatal sepsis (both monotherapies and combination therapies). Both reviewers screened abstracts and full reports against the inclusion criteria, appraised the quality of and extracted data from papers. For dichotomous outcomes, treatment effect was expressed as relative risk with 95% confidence interval. Meta-analysis was performed using a fixed effect model. Two small studies had compared monotherapy with combination therapy. There was no significant difference in mortality, treatment failure or bacteriological resistance. There is no evidence from randomised trials to suggest that any antibiotic regimen may be better than any other in the treatment of presumed early neonatal sepsis. More studies are needed to resolve this issue.
Related Links	http://onlinelibrary.wiley.com/doi/10.1002/14651858.CD004495.pub2/pdf
ISSN	1469493X
e-ISSN	14651858
DOI	10.1002/14651858.cd004495.pub2
Journal	Cochrane Database of Systematic Reviews
Issue Number	7
Volume Number	2021
Language	English
Publisher	Wiley-Blackwell
Publisher Date	2004-10-18
Access Restriction	Open
Subject Keyword	Journal: Cochrane Database of Systematic Reviews Obstetrics and Gynecology Early Neonatal Sepsis Antibiotic Regimens
Content Type	Text
Resource Type	Article

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