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Modulation of Fibrin Cofactor Activity in Plasminogen Activation
| Content Provider | Scilit |
|---|---|
| Author | Nesheim, Michael Walker, John Wang, Wei Boffa, Michael Horrevoets, Anton Bajzar, Laszlo |
| Copyright Year | 2006 |
| Description | Journal: Annals of the New York Academy of Sciences Fibrin is a cofactor for the formation of plasmin from plasminogen as catalyzed by tissue plasminogen activator. Initial cleavages of fibrin by plasmin upregulates the cofactor activity of fibrin by exposing carboxyl terminal lysine residues. This effect is eliminated by a carboxypeptidase B‐like enzyme generated from the precursor, thrombin activatable fibrinolysis inhibitor (TAFI) that is generated by thrombin during the formation of fibrin. Thus, TAFI and its activation to TAFIa create a link between the coagulation and fibrinolytic cascade, such that activation of the former suppresses the latter. Complete solubilization of fibrin results in a family of very large fibrin degradation products. These also have very substantial tissue plasminogen activator cofactor activity that is very highly downregulated by TAFIa. |
| Related Links | https://nyaspubs.onlinelibrary.wiley.com/doi/pdf/10.1111/j.1749-6632.2001.tb03513.x |
| Ending Page | 260 |
| Page Count | 14 |
| Starting Page | 247 |
| e-ISSN | 17496632 |
| DOI | 10.1111/j.1749-6632.2001.tb03513.x |
| Journal | Annals of the New York Academy of Sciences |
| Issue Number | 1 |
| Volume Number | 936 |
| Language | English |
| Publisher | Wiley-Blackwell |
| Publisher Date | 2006-01-25 |
| Access Restriction | Open |
| Subject Keyword | Journal: Annals of the New York Academy of Sciences Tissue Plasminogen Activator Thrombin Activatable Fibrinolysis Inhibitor |
| Content Type | Text |
| Resource Type | Article |
