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Intracellular calcium signalling in magnocellular neurones of the rat supraoptic nucleus: understanding the autoregulatory mechanisms
| Content Provider | Scilit |
|---|---|
| Author | Dayanithi, Govindan Sabatier, Nancy Widmer, Hélène |
| Copyright Year | 2000 |
| Description | Journal: Experimental Physiology Oxytocin and vasopressin, released at the soma and dendrites of neurones, bind to specific autoreceptors and induce an increase in [Ca^{2+}$]_{1}$. In oxytocin cells, the increase results from a mobilisation of $Ca^{2+}$ from intracellular stores, whereas in vasopressin cells, it results mainly from an influx of $Ca^{2+}$ through voltage‐dependent channels. The response to vasopressin is coupled to phospholipase C and adenylyl‐cyclase pathways which are activated by $V_{1}$ $(V_{1a}$ and $V_{1b}$)‐ and $V_{2}$‐type receptors respectively. Measurements of [Ca^{2+}$]_{1}$ in response to $V_{1a}$ and $V_{2}$ agonists and antagonists suggest the functional expression of these two types of receptors in vasopressin neurones. The intracellular mechanisms involved are similar to those observed for the action of the pituitary adenylyl‐cyclase‐activating peptide (PACAP). Isolated vasopressin neurones exhibit spontaneous [Ca^{2+}$]_{1}$ oscillations and these are synchronised with phasic bursts of electrical activity. Vasopressin modulates these spontaneous [Ca^{2+}$]_{1}$ oscillations in a manner that depends on the initial state of the neurone, and such varied effects of vasopressin may be related to those observed on the electrical activity of vasopressin neurones in vivo. |
| Ending Page | 84s |
| Starting Page | 75s |
| ISSN | 2573508X |
| e-ISSN | 1469445X |
| DOI | 10.1111/j.1469-445x.2000.tb00010.x |
| Journal | Experimental Physiology |
| Issue Number | s1 |
| Volume Number | 85 |
| Language | English |
| Publisher | Wiley-Blackwell |
| Publisher Date | 2000-03-01 |
| Access Restriction | Open |
| Subject Keyword | Journal: Experimental Physiology Vasopressin Neurones |
| Content Type | Text |
| Resource Type | Article |
