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Acid-labile anchoring linkages for solid phase synthesis of C-terminal asparagine peptides using the Fmoc strategy
| Content Provider | Scilit |
|---|---|
| Author | Shao, Jun Li, You-He Voelter, Wolfgang |
| Copyright Year | 2009 |
| Description | Journal: International journal of peptide and protein research Two acid-labile substituted benzylamine type anchoring linkages, 4-benzoxy-2,6-dimethoxybenzylamine and 2-benzoxy-4,6-dimethoxybenzylamine, for solid phase synthesis of peptide amides were prepared. The Na-9-fluorenylmethyloxycarbonyl (Fmoc) amino acids could be easily attached to the resins with DCC/HOBt (loading 0.5-0.6 mmol/g resin). After final removal of the Na-protecting groups, treatment with TFA (50-95%) yielded amino acid and peptide amides in high purity. As we could show for the synthesis of thymulin (FTS, pGlu-Ala-Lys-Ser-Gln-Gly-Gly-Ser-Asn), these two resins with anchoring linkages are well suited for the synthesis of C-terminal Asn peptides using protected aspartic acid derivative as starting material. |
| Related Links | http://onlinelibrary.wiley.com/doi/10.1111/j.1399-3011.1990.tb00964.x/pdf |
| Ending Page | 187 |
| Page Count | 6 |
| Starting Page | 182 |
| ISSN | 03678377 |
| DOI | 10.1111/j.1399-3011.1990.tb00964.x |
| Journal | International journal of peptide and protein research |
| Issue Number | 2 |
| Volume Number | 36 |
| Language | English |
| Publisher | Wiley-Blackwell |
| Publisher Date | 2009-01-12 |
| Access Restriction | Open |
| Subject Keyword | Journal: International journal of peptide and protein research Acid‐labile Amide Anchoring Linkage Fmoc Amino Acids Solid Phase Peptide Synthesis Synthesis of C‐terminal Asn Peptides |
| Content Type | Text |
| Resource Type | Article |
| Subject | Biochemistry |
