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Phospholamban Ablation and Compensatory Responses in the Mammalian Heart a
| Content Provider | Scilit |
|---|---|
| Author | Chu, Guoxiang Ferguson, Donald G. Edes, Istvan Kiss, Eva Sato, Yoji Kranias, Evangelia G. |
| Copyright Year | 1998 |
| Description | Journal: Annals of the New York Academy of Sciences Phospholamban is a low molecular weight phosphoprotein in cardiac sarcoplasmic reticulum. The regulatory role of phospholamban in vivo has recently been elucidated by targeting the gene of this protein in embryonic stem cells and generating phospholamban‐deficient mice. The phospholamban knockout hearts exhibited significantly enhanced contractile parameters and attenuated responses to β‐agonists. The hyperdynamic cardiac function of the phospholamban knockout mice was not accompanied by any cytoarchitectural abnormalities or alterations in the expression levels of the cardiac sarcoplasmic reticulum $Ca^{2+}$‐ATPase, calsequestrin, $Na^{+}‐Ca^{2+}$ exchanger, or the contractile proteins. Furthermore, the attenuation of the cardiac responses to β‐agonists was not due to alterations in the phosphorylation levels of the other key cardiac phosphoproteins in the phospholamban knockout hearts. However, ablation of phospholamban was associated with down‐regulation of the ryanodine receptor, which suggests that a cross‐talk between cardiac sarcoplasmic reticulum $Ca^{2+}$ uptake and $Ca^{2+}$ release occurred in an attempt to maintain $Ca^{2+}$ homeostasis in these hyperdynamic phospholamban knockout hearts. |
| Related Links | https://nyaspubs.onlinelibrary.wiley.com/doi/pdf/10.1111/j.1749-6632.1998.tb08256.x |
| Ending Page | 62 |
| Page Count | 14 |
| Starting Page | 49 |
| e-ISSN | 17496632 |
| DOI | 10.1111/j.1749-6632.1998.tb08256.x |
| Journal | Annals of the New York Academy of Sciences |
| Issue Number | 1 CARDIAC |
| Volume Number | 853 |
| Language | English |
| Publisher | Wiley-Blackwell |
| Publisher Date | 1998-09-01 |
| Access Restriction | Open |
| Subject Keyword | Journal: Annals of the New York Academy of Sciences Cell Tissue Engineering Embryonic Stem Cells Cardiac Sarcoplasmic Sarcoplasmic Reticulum |
| Content Type | Text |
| Resource Type | Article |
