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Prenatal diagnosis of lobar holoprosencephaly
| Content Provider | Scilit |
|---|---|
| Author | Pilu, G. Sandri, F. Perolo, A. Giangaspero, F. Cocchi, G. Salvioli, G. P. Bovicelli, L. |
| Copyright Year | 1992 |
| Description | Journal: Ultrasound in Obstetrics & Gynecology Lobar holoprosencephaly was identified with sonography in 12 fetuses between 21 and 35 weeks' gestation. A confident diagnosis was made in each case by a mid-coronal view of the brain demonstrating absence of the cavum septum pellucidum with fusion and squaring of the frontal horns. The only associated anomaly was Dandy-Walker malformation that occurred in three cases. All fetuses had mild to severe ventriculomegaly. Five pregnancies were terminated; there was one spontaneous abortion and six fetuses were delivered at term. A ventriculo-peritoneal shunt was implanted in four. Follow-up was available for five and revealed severe mental retardation in each case. Lobar holoprosencephaly is amenable to prenatal ultrasound diagnosis, although a differentiation with other cerebral malformations may be difficult at times. The outcome of affected infants remains uncertain, but neurological impairment occurs frequently. |
| Related Links | http://onlinelibrary.wiley.com/doi/10.1046/j.1469-0705.1992.02020088.x/pdf |
| Ending Page | 94 |
| Page Count | 7 |
| Starting Page | 88 |
| e-ISSN | 14690705 |
| DOI | 10.1046/j.1469-0705.1992.02020088.x |
| Journal | Ultrasound in Obstetrics & Gynecology |
| Issue Number | 2 |
| Volume Number | 2 |
| Language | English |
| Publisher | Wiley-Blackwell |
| Publisher Date | 1992-03-01 |
| Access Restriction | Open |
| Subject Keyword | Journal: Ultrasound in Obstetrics & Gynecology Pediatrics and Child Health Prenatal Diagnosis Congenital Anomalies Holoprosencephaly |
| Content Type | Text |
| Resource Type | Article |
