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Association between serum estradiol levels prior to progesterone administration in artificial frozen–thawed blastocyst transfer cycles and live birth rate: a retrospective study
| Content Provider | Scilit |
|---|---|
| Author | Zhou, Ruiqiong Zhang, Xiqian Huang, Li Zhu, Xiulan Dong, Mei Liu, Wenjuan Wang, Songlu Liu, Fenghua |
| Copyright Year | 2021 |
| Description | Journal: BJOG Objective To study whether serum estradiol levels prior to progesterone administration in artificial endometrial preparation (AEP) of frozen blastocyst transfer affect live birth rate (LBR). Design Retrospective cohort study. Setting Tertiary-care academic medical center. Population A total of 3857 frozen-thawed blastocyst transfer cycles were divided into three groups:< 200 pg/ml (n = 1676), 200–399 pg/ml (n = 1296), and ≥ 400 pg/ml (n = 885), based on the 25th (182.3 pg/ml) and 75th percentile (390.2 pg/ml) of serum E2 level prior to progesterone administration. Methods Univariable and multivariable logistic regression analysis was performed. Main Outcome Measures The primary outcome of the study was LBR and the secondary outcomes included clinical pregnancy rate, pregnancy loss rate, neonatal birthweight, Z-score and small for gestational age (SGA). Results Compared with the reference group, accounting for major covariates, LBR significantly decreased in the “≥ 400 pg/ml” group (adjusted OR = 0.71; 95% CI, 0.59–0.85). Compared with the reference group, there was an association between the E2 level in the “≥400 pg/ml” group and the decrease in clinical pregnancy rate (adjusted OR = 0.74; 95% CI, 0.61–0.89). Compared with the reference group, pregnancy loss rate significantly increased in the “≥ 400 pg/ml” group (adjusted OR = 1.45; 95% CI, 1.08–1.93). The E2 levels did not affect neonatal birthweight, Z-score, and SGA among singletons. Conclusion High serum E2 levels prior to progesterone administration in AEP are associated with decreased LBR after frozen-thawed blastocyst transfer. |
| Ending Page | 2100 |
| Starting Page | 2092 |
| ISSN | 2573508X |
| e-ISSN | 14710528 |
| DOI | 10.1111/1471-0528.16777 |
| Journal | BJOG |
| Issue Number | 13 |
| Volume Number | 128 |
| Language | English |
| Publisher | Wiley-Blackwell |
| Publisher Date | 2021-05-28 |
| Access Restriction | Open |
| Subject Keyword | Journal: BJOG Obstetrics and Gynecology Reproductive Biology Frozen-thawed Embryo Transfer Live Birth Rate Artificial Endometrial Preparation |
| Content Type | Text |
| Resource Type | Article |
