NDLI: Inhibition by Forskolin of Excitatory Amino Acid-Induced Accumulation of Cyclic AMP in Guinea Pig Hippocampal Slices

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Inhibition by Forskolin of Excitatory Amino Acid-Induced Accumulation of Cyclic AMP in Guinea Pig Hippocampal Slices

Content Provider	Scilit
Author	Baba, Akemichi Nishiuchi, Yukiko Uemura, Atsuhiro Tatsuno, Tohru Iwata, Heitaroh
Copyright Year	1988
Description	Journal: Journal of Neurochemistry The effect of forskolin on the excitatory amino acid-induced accumulation of cyclic AMP was examined in hippocampal preparations of the guinea pig. Forskolin at concentrations of 0.1-10 microM remarkably enhanced the stimulatory effects of histamine and adenosine, whereas it markedly attenuated the stimulation induced by cysteine sulfinate, an excitatory amino acid. Forskolin reduced the maximal response to cysteine sulfinate without affecting the apparent ED50. At a concentration of 1 microM, forskolin also inhibited the stimulatory effects of glutamate, N-methyl-DL-aspartate, and veratridine without affecting those of kainate and quisqualate. Pretreatment of the slices with 0.1 mM N-ethylmaleimide partially prevented the attenuation by forskolin of cysteine sulfinate-induced accumulation of cyclic AMP without affecting the stimulation induced by cysteine sulfinate. Forskolin at concentrations of less than 1 microM did not affect GTP-stimulated activity and Cl- -dependent activity of adenylate cyclase of the hippocampal membranes.
Related Links	http://onlinelibrary.wiley.com/doi/10.1111/j.1471-4159.1988.tb04861.x/pdf
Ending Page	242
Page Count	6
Starting Page	237
e-ISSN	14714159
DOI	10.1111/j.1471-4159.1988.tb04861.x
Journal	Journal of Neurochemistry
Issue Number	1
Volume Number	51
Language	English
Publisher	Wiley-Blackwell
Publisher Date	1988-07-01
Access Restriction	Open
Subject Keyword	Journal: Journal of Neurochemistry Excitatory Amino Acid Adenylate Cyclase Inhibitory Guanine Nucleotide Protein
Content Type	Text
Resource Type	Article

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