NDLI: Adipose Gene Expression Profile Changes With Lung Allograft Reperfusion

Please wait, while we are loading the content...

Adipose Gene Expression Profile Changes With Lung Allograft Reperfusion

Content Provider	Scilit
Author	D'Ovidio, F. D'Errico, C. Diamond, J. M. Arcasoy, S. McDonnough, J. A. Sonett, J. R. Bacchetta, M. Cantu, E. Bermudez, C. A. McBurnie, A. Rushefski, M. Kalman, L. H. Oyster, M. Suzuki, Y. Giles, J. T. Ferrante, A. Lippel, M. Singh, G. Lederer, D. J. Christie, J. D.
Copyright Year	2016
Description	Journal: American Journal of Transplantation Obesity is a risk factor for primary graft dysfunction (PGD), a form of lung injury resulting from ischemia-reperfusion after lung transplantation, but the impact of ischemia-reperfusion on adipose tissue is unknown. We evaluated differential gene expression in thoracic visceral adipose tissue (VAT) before and after lung reperfusion. Total RNA was isolated from thoracic VAT sampled from six subjects enrolled in the Lung Transplant Body Composition study before and after allograft reperfusion and quantified using the Human Gene 2.0 ST array. Kyoto Encyclopedia of Genes and Genomes pathway analysis revealed enrichment for genes involved in complement and coagulation cascades and Jak-STAT signaling pathways. Overall, 72 genes were upregulated and 56 genes were downregulated in the postreperfusion time compared with baseline. Long pentraxin-3, a gene and plasma protein previously associated with PGD, was the most upregulated gene (19.5-fold increase, p = 0.04). Fibronectin leucine-rich transmembrane protein-3, a gene associated with cell adhesion and receptor signaling, was the most downregulated gene (4.3-fold decrease, p = 0.04). Ischemia-reperfusion has a demonstrable impact on gene expression in visceral adipose tissue in our pilot study of nonobese, non-PGD lung transplant recipients. Future evaluation will focus on differential adipose tissue gene expression and the development of PGD after transplant.
Related Links	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5195853/pdf
Ending Page	245
Page Count	7
Starting Page	239
e-ISSN	16006143
DOI	10.1111/ajt.13964
Journal	American Journal of Transplantation
Issue Number	1
Volume Number	17
Language	English
Publisher	Wiley-Blackwell
Publisher Date	2016-08-18
Access Restriction	Open
Subject Keyword	Journal: American Journal of Transplantation Ischemia Reperfusion Injury (iri) Lung (allograft) Function/dysfunction Lung Transplantation/pulmonology Translational Research/science
Content Type	Text
Resource Type	Article

Sl.	Authority	Responsibilities	Communication Details
1	Ministry of Education (GoI), Department of Higher Education	Sanctioning Authority	https://www.education.gov.in/ict-initiatives
2	Indian Institute of Technology Kharagpur	Host Institute of the Project: The host institute of the project is responsible for providing infrastructure support and hosting the project	https://www.iitkgp.ac.in
3	National Digital Library of India Office, Indian Institute of Technology Kharagpur	The administrative and infrastructural headquarters of the project	Dr. B. Sutradhar bsutra@ndl.gov.in
4	Project PI / Joint PI	Principal Investigator and Joint Principal Investigators of the project	Dr. B. Sutradhar bsutra@ndl.gov.in Prof. Saswat Chakrabarti will be added soon
5	Website/Portal (Helpdesk)	Queries regarding NDLI and its services	support@ndl.gov.in
6	Contents and Copyright Issues	Queries related to content curation and copyright issues	content@ndl.gov.in
7	National Digital Library of India Club (NDLI Club)	Queries related to NDLI Club formation, support, user awareness program, seminar/symposium, collaboration, social media, promotion, and outreach	clubsupport@ndl.gov.in
8	Digital Preservation Centre (DPC)	Assistance with digitizing and archiving copyright-free printed books	dpc@ndl.gov.in
9	IDR Setup or Support	Queries related to establishment and support of Institutional Digital Repository (IDR) and IDR workshops	idr@ndl.gov.in

Mitochondrial damage–associated molecular patterns released by lung transplants are associated with primary graft dysfunction

Protein Quantitative Trait Loci Analysis Identifies Genetic Variation in the Innate Immune Regulator TOLLIP in Post–Lung Transplant Primary Graft Dysfunction Risk

Peripheral Blood Gene Expression Changes Associated With Primary Graft Dysfunction After Lung Transplantation

Impact of Allograft Injury Time of Onset on the Development of Chronic Lung Allograft Dysfunction After Lung Transplantation

Noninvasive Imaging of $CCR2^{+}$Cells in Ischemia-Reperfusion Injury After Lung Transplantation

Noninvasive Imaging of Activated Complement in Ischemia-Reperfusion Injury Post-Cardiac Transplant

VEGF mitigates histone-induced pyroptosis in the remote liver injury associated with renal allograft ischemia-reperfusion injury in rats

Objective Estimates Improve Risk Stratification for Primary Graft Dysfunction after Lung Transplantation

Donor pretreatment with nebulized complement C3a receptor antagonist mitigates brain-death induced immunological injury post-lung transplant

Adipose Gene Expression Profile Changes With Lung Allograft Reperfusion

Similar Documents

Mitochondrial damage–associated molecular patterns released by lung transplants are associated with primary graft dysfunction

Protein Quantitative Trait Loci Analysis Identifies Genetic Variation in the Innate Immune Regulator TOLLIP in Post–Lung Transplant Primary Graft Dysfunction Risk

Peripheral Blood Gene Expression Changes Associated With Primary Graft Dysfunction After Lung Transplantation

Impact of Allograft Injury Time of Onset on the Development of Chronic Lung Allograft Dysfunction After Lung Transplantation

Noninvasive Imaging of $CCR2^{+}$Cells in Ischemia-Reperfusion Injury After Lung Transplantation

Noninvasive Imaging of Activated Complement in Ischemia-Reperfusion Injury Post-Cardiac Transplant

VEGF mitigates histone-induced pyroptosis in the remote liver injury associated with renal allograft ischemia-reperfusion injury in rats

Objective Estimates Improve Risk Stratification for Primary Graft Dysfunction after Lung Transplantation

Donor pretreatment with nebulized complement C3a receptor antagonist mitigates brain-death induced immunological injury post-lung transplant

Adipose Gene Expression Profile Changes With Lung Allograft Reperfusion