Abrogation of Chk 1-mediated S / G 2 checkpoint by UCN-01 enhances araC-induced cytotoxicity in human colon cancer cells 1

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Enhancement of cisplatin-induced cytotoxicity by 7-hydroxystaurosporine (UCN-01), a new G2-checkpoint inhibitor.

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Determinants of mitotic catastrophe upon abrogation of the G2 DNA damage checkpoint by UCN-01

Therapeutic Discovery Determinants of Mitotic Catastrophe on Abrogation of the G2 DNA Damage Checkpoint by UCN-01

Potentiation of cytotoxicity of topoisomerase i poison by concurrent and sequential treatment with the checkpoint inhibitor UCN-01 involves disparate mechanisms resulting in either p53-independent clonogenic suppression or p53-dependent mitotic catastrophe.

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Enhancement of antitumor activity of mitomycin C in vitro and in vivo by UCN-01, a selective inhibitor of protein kinase C

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Abrogation of the radiation-induced G2 checkpoint by the staurosporine derivative UCN-01 is associated with radiosensitisation in a subset of colorectal tumour cell lines

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UCN-01: a Potent Abrogator of G2 Checkpoint Function in Cancer Cells With Disrupted p53

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Blocking chk1 expression induces apoptosis and abrogates the g2 checkpoint mechanism.