Loading...
Please wait, while we are loading the content...
Similar Documents
Efficacy and safety of recombinant human epidermal growth factor for diabetic foot ulcers: A systematic review and meta‐analysis of randomised controlled trials
| Content Provider | Scilit |
|---|---|
| Author | Zhao, Ding‐Yun Su, Ya‐Na Li, Yong‐Hong Yu, Tian‐Qi Li, Jing Tu, Chong‐Qi |
| Copyright Year | 2020 |
| Description | Journal: International Wound Journal To evaluate the efficacy and safety of recombinant human epidermal growth factor (rhEGF) in treating diabetic foot ulcers (DFUs), we conducted both database searches (PubMed, MEDLINE, EMBASE, CENTRAL, and Web of Science) and reference searches for randomised controlled trials from the inception of databases to 30 January 2020. Two reviewers independently scrutinised the trials, extracted data, and assessed the quality of trials. The primary outcome was the proportion of complete healing. The secondary outcomes were mean time to complete healing and adverse events. A subgroup analysis was performed by different administration routes. Statistical analyses were performed in RevMan 5.3. The time to complete healing Kaplan‐Meier curves was pooled in the R software. Of the 156 citations, 9 trials (720 participants) met eligibility criteria and were included. The rhEGF achieved a higher complete healing rate than placebo (OR: 2.79, [95% CI: 1.99, 3.99]). The rhEGF also significantly shorten complete healing time (MD: −14.10 days, [95% CI: −18.03, −10.16]). Subgroup analysis showed that topical application was superior to intralesional injection, but that may be because of different ulcer severity they included. No significant difference was shown in adverse events. Results were coherent with sensitivity analyses. Therefore, rhEGF is an effective and safe treatment for DFUs. |
| Ending Page | 1073 |
| Starting Page | 1062 |
| ISSN | 00221295 |
| e-ISSN | 1742481X |
| DOI | 10.1111/iwj.13377 |
| Journal | International Wound Journal |
| Issue Number | 4 |
| Volume Number | 17 |
| Language | English |
| Publisher | Wiley-Blackwell |
| Publisher Date | 2020-08-01 |
| Access Restriction | Open |
| Subject Keyword | Journal: International Wound Journal Diabetic Foot Ulcer Recombinant Human Epidermal Growth Factor Systematic Review |
| Content Type | Text |
| Resource Type | Article |
| Subject | Surgery Dermatology |
