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Effect of Unilateral Perinatal Hypoxic-Ischemic Brain Injury in the Rat on Dopamine $D_{1}$and $D_{2}$Receptors and Uptake Sites: A Quantitative Autoradiographic Study
| Content Provider | Scilit |
|---|---|
| Author | Przedborski, Serge Kostic, Vladimir Jackson-Lewis, Vernice Cadet, Jean Lud Burke, Robert E. |
| Copyright Year | 1991 |
| Description | Journal: Journal of Neurochemistry The effect of a unilateral perinatal hypoxic-ischemic brain injury on dopamine $D_{1}$ and $D_{2}$ receptors and uptake sites was investigated in rats by using in vitro quantitative binding autoradiography, 2–3 weeks after the insult. We observed significant decreases in the $B_{max}$ and $K_{D}$ for $[^{3}$H]SCH 23390-labeled $D_{1}$ and in the $B_{max}$ for $[^{3}$H]spiperone-labeled $D_{2}$ receptors in the lesioned caudate-putamen in rats with moderate brain injury (visible loss in hemispheric volume ipsilateral to the injury) compared with the nonlesioned contralateral caudate-putamen or with control rats. Changes in $[^{3}$H]SCH 23390 and $[^{3}$H]spiperone binding predominated in the dorsolateral part of the lesioned caudate-putamen. Pronounced reduction in $[^{3}$H]SCH 23390 binding was also observed in the substantia nigra pars reticulata on the side of the lesion. In contrast, we did not observe any significant change in $B_{max}$ or $K_{D}$ for $[^{3}$H]mazindol-labeled dopamine uptake sites. Similarly, no significant changes in the levels of dopamine or its metabolites were found on the side of the lesion. The observed reductions in striatal dopamine $D_{1}$ and $D_{2}$ receptors are a reflection of striatal cell loss induced by the hypoxic-ischemic injury. The absence of changes in $[^{3}$H]mazindoI binding or dopamine levels in the lesioned caudate-putamen indicates that the dopaminergic presynaptic structures are preserved. |
| Related Links | https://onlinelibrary.wiley.com/doi/pdf/10.1111/j.1471-4159.1991.tb06409.x |
| Ending Page | 1961 |
| Page Count | 11 |
| Starting Page | 1951 |
| e-ISSN | 14714159 |
| DOI | 10.1111/j.1471-4159.1991.tb06409.x |
| Journal | Journal of Neurochemistry |
| Issue Number | 6 |
| Volume Number | 57 |
| Language | English |
| Publisher | Wiley-Blackwell |
| Publisher Date | 1991-12-01 |
| Access Restriction | Open |
| Subject Keyword | Journal: Journal of Neurochemistry Hypoxia—ischemia—striatum—dystonia—[3h]sch 23390—[3h]spiperone—[3h]mazindol. Przedborski S. Et Al. Effect of Unilateral Perinatal Hypoxic-ischemic Brain Injury in the Rat On Dopamine D1 and D2 Receptors and Uptake Sites: A Quantitative Auto-radiographic Study |
| Content Type | Text |
| Resource Type | Article |
