NDLI: Identification of Eight Synthetic Cannabinoids, Including 5F-AKB48 in Seized Herbal Products Using DART-TOF-MS and LC-QTOF-MS as Nontargeted Screening Methods

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Identification of Eight Synthetic Cannabinoids, Including 5F-AKB48 in Seized Herbal Products Using DART-TOF-MS and LC-QTOF-MS as Nontargeted Screening Methods

Content Provider	Scilit
Author	Moore, Katherine N. Garvin, Demetra Thomas, Brian F. Grabenauer, Megan
Copyright Year	2017
Description	Journal: Journal of Forensic Sciences Synthetic cannabinoids are sprayed onto plant material and smoked for their marijuana-like effects. Clandestine manufacturers modify synthetic cannabinoid structures by creating closely related analogs. Forensic laboratories are tasked with detection of these analog compounds, but targeted analytical methods are often thwarted by the structural modifications. Here, direct analysis in real time coupled to accurate mass time-of-flight mass spectrometry (DART-TOF-MS) in combination with liquid chromatography quadruple time-of-flight mass spectrometry (LC-QTOF-MS) are presented as a screening and nontargeted confirmation method, respectively. Methanol extracts of herbal material were run using both methods. Spectral data from four different herbal products were evaluated by comparing fragmentation pattern, accurate mass and retention time to available reference standards. JWH-018, JWH-019, AM2201, JWH-122, 5F-AKB48, AKB48-N-(4-pentenyl) analog, UR144, and XLR11 were identified in the products. Results demonstrate that DART-TOF-MS affords a useful approach for rapid screening of herbal products for the presence and identification of synthetic cannabinoids.
Related Links	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6391873/pdf
Ending Page	1158
Page Count	8
Starting Page	1151
e-ISSN	15564029
DOI	10.1111/1556-4029.13367
Journal	Journal of Forensic Sciences
Issue Number	5
Volume Number	62
Language	English
Publisher	Wiley-Blackwell
Publisher Date	2017-06-09
Access Restriction	Open
Subject Keyword	Journal: Journal of Forensic Sciences Legal Medicine Direct Analysis in Real Time Forensic Science Herbal Products Mass Spectrometry Nontargeted Analysis Synthetic Cannabinoids
Content Type	Text
Resource Type	Article

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