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Accuracy of Two Cognitive Screening Tools to Detect Mild Cognitive Impairment in Parkinson's Disease
| Content Provider | Scilit |
|---|---|
| Author | Koevoets, Emmie W. Schmand, Ben Geurtsen, G. J. |
| Copyright Year | 2018 |
| Description | Journal: Movement Disorders Clinical Practice Background: Patients with Parkinson's disease (PD) who have mild cognitive impairment (PD-MCI) are at increased risk of developing PD dementia (PDD). Therefore, it is important to identify PD-MCI in a reliable way. Objectives: We evaluated the accuracy of the Parkinson's Disease-Cognitive Rating Scale (PD-CRS) and the Mattis Dementia Rating Scale-2 (MDRS-2) for detecting PD-MCI. Data from healthy subjects were used to correct for demographic influences. Methods: We compared the accuracy of the two instruments using ROC analysis. The gold standard was level II diagnosis of PD-MCI according to consensus criteria of the International Parkinson and Movement Disorder Society. Results: Seventy-five healthy subjects and 125 PD patients were included. Education level, age and sex correlated with the PD-CRS, but only age correlated with the MDRS-2. Twenty-seven percent of the patients had PD-MCI. Areas under the curve (AUCs) for raw scores of PD-CRS and MDRS-2 were 0.83 and 0.81, respectively. At the optimal cut-off for the PD-CRS (101/102), sensitivity was 88% and specificity was 64%. For the MDRS-2 (139/140) sensitivity and specificity were 68% and 79%, respectively. AUCs for demographically corrected scores of PD-CRS and for age-corrected scores of MDRS-2 were 0.80 and 0.78, respectively. At the optimal cut-off for the PD-CRS, sensitivity was 79% and specificity was 72%, while for the MDRS-2 these were 77% and 67%, respectively. Conclusions: Both cognitive screening tools are suitable for distinguishing PD-MCI patients from cognitively intact PD patients. Demographical correction of scores did not improve sensitivity and specificity. This article is protected by copyright. All rights reserved. |
| Related Links | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6174373/pdf |
| Ending Page | 264 |
| Page Count | 6 |
| Starting Page | 259 |
| ISSN | 23301619 |
| e-ISSN | 23301619 |
| DOI | 10.1002/mdc3.12597 |
| Journal | Movement Disorders Clinical Practice |
| Issue Number | 3 |
| Volume Number | 5 |
| Language | English |
| Publisher | Wiley-Blackwell |
| Publisher Date | 2018-05-01 |
| Access Restriction | Open |
| Subject Keyword | Journal: Movement Disorders Clinical Practice Nutrition and Dietetics Parkinson's Disease Mild Cognitive Impairment Parkinson's Disease‐cognitive Rating Scale Mattis Dementia Rating Scale‐2 Cognitive Screening |
| Content Type | Text |
| Resource Type | Article |
| Subject | Neurology Neurology (clinical) |
