NDLI: Treatment of Helicobacter pylori: an overview

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Treatment of Helicobacter pylori: an overview

Content Provider	Scilit
Author	Axon, A. T. R.
Copyright Year	2000
Description	Journal: Alimentary Pharmacology & Therapeutics Helicobacter pylori is recognized to be a serious pathogen, but there is still controversy as to who should be treated. There is consensus for treatment of Helicobacter‐positive peptic ulcer and B‐cell lymphoma. Lymphocytic gastritis and giant‐fold gastritis (Ménétrièr's disease) may also respond to treatment. Patients with func‐tional dyspepsia have a 20% placebo response with a 5–10% ‘eradication’ response, results not dissimilar from empirical treatment with a proton pump inhibitor. A ‘test and treat’ policy for patients with uninvesti‐gated dyspepsia remains controversial. Some have suggested that eradication may increase the risk of GERD, or predispose to adenocarcinoma at the gastro‐oesophageal junction. However, PPI treatment without Helicobacter eradication induces greater inflammation in the gastric corpus, the phenotype associated with non‐cardia gastric cancer. A minority believe that Helicobacter should be eradicated in all individuals. When choosing treatment it is logical to start with a combination of antibiotics that, in the event of failure, will allow a second combination to be used without overlap.
Ending Page	6
Starting Page	1
ISSN	2573508X
e-ISSN	13652036
DOI	10.1046/j.1365-2036.2000.00394.x
Journal	Alimentary Pharmacology & Therapeutics
Volume Number	14
Language	English
Publisher	Wiley-Blackwell
Publisher Date	2000-10-01
Access Restriction	Open
Subject Keyword	Journal: Alimentary Pharmacology & Therapeutics Gastroenterology and Hepatology Helicobacter Pylori
Content Type	Text
Resource Type	Article

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