NDLI: Basal forebrain atrophy and cortical amyloid deposition in nondemented elderly subjects

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Basal forebrain atrophy and cortical amyloid deposition in nondemented elderly subjects

Content Provider	Scilit
Author	Grothe, Michel J. Ewers, Michael Krause, Bernd Heinsen, Helmut Teipel, Stefan J.
Copyright Year	2014
Description	Journal: Alzheimer's & Dementia Both neurodegeneration of the cholinergic basal forebrain (BF) and deposition of β-amyloid are early events in the course of Alzheimer's disease (AD). Associations between increased amyloid pathology and cholinergic atrophy have been described in autopsy studies. We used structural MRI and AV45-PET amyloid imaging data of 225 cognitively normal or mildly impaired elderly subjects from the Alzheimer's Disease Neuroimaging Initiative to assess in vivo associations between BF atrophy and cortical amyloid deposition. Associations were examined using region-of-interest (ROI) and voxel-based approaches with reference to cytoarchitectonic mappings of the cholinergic BF nuclei. ROI- and voxel-based approaches yielded complementary evidence for an association between BF volume and cortical amyloid deposition in presymptomatic and predementia stages of AD, irrespective of age, gender, and APOE genotype. The observed correlations between BF atrophy and cortical amyloid load likely reflect associations between cholinergic degeneration and amyloid pathology as reported in neuropathologic examination studies.
Related Links	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4092050/pdf
e-ISSN	15525279
DOI	10.1016/j.jalz.2013.09.011
Journal	Alzheimer's & Dementia
Issue Number	5S
Volume Number	10
Language	English
Publisher	Wiley-Blackwell
Publisher Date	2014-01-13
Access Restriction	Open
Subject Keyword	Journal: Alzheimer's & Dementia Alzheimer's Disease Cholinergic Basal Forebrain Cytoarchitectonic Mild Cognitive Impairment Nucleus Basalis Meynert Substantia Innominata
Content Type	Text
Resource Type	Article

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