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Sustained virological response rates and health-related quality of life after interferon and ribavirin therapy in patients with chronic hepatitis C virus infection and persistently normal alanine aminotransferase levels
| Content Provider | Scilit |
|---|---|
| Author | Bini, E. J. Mehandru, S. |
| Copyright Year | 2006 |
| Description | Journal: Alimentary Pharmacology & Therapeutics Few studies have evaluated interferon and ribavirin therapy in hepatitis C virus-infected patients with persistently normal alanine aminotransferase (ALT) levels. To determine the efficacy and safety of combination therapy in this population, and to evaluate the impact of treatment on health-related quality of life. Forty-six hepatitis C virus-infected patients with persistently normal ALT levels and 92 matched subjects with elevated ALT levels were treated with interferon-alpha2b plus ribavirin for up to 48 weeks. Health-related quality of life was measured prior to therapy and 24 weeks after completion of treatment using the Hepatitis Quality of Life Questionnaire. Overall, 32.6% of patients with normal ALT levels and 28.3% of those with elevated ALT levels had undetectable hepatitis C virus RNA at 24 weeks after completion of treatment (P = 0.60). Three patients in the normal ALT group had mild transient ALT elevations during therapy. Compared with baseline, treatment was associated with significant improvements in nearly all domains of health-related quality of life in both groups of patients. In hepatitis C virus-infected patients with persistently normal ALT levels, interferon-alpha and ribavirin therapy is efficacious, safe, and associated with significant improvements in health-related quality of life. |
| Related Links | http://onlinelibrary.wiley.com/doi/10.1111/j.1365-2036.2006.02819.x/pdf |
| Ending Page | 785 |
| Page Count | 9 |
| Starting Page | 777 |
| e-ISSN | 13652036 |
| DOI | 10.1111/j.1365-2036.2006.02819.x |
| Journal | Alimentary Pharmacology & Therapeutics |
| Issue Number | 6 |
| Volume Number | 23 |
| Language | English |
| Publisher | Wiley-Blackwell |
| Publisher Date | 2006-03-01 |
| Access Restriction | Open |
| Subject Keyword | Journal: Alimentary Pharmacology & Therapeutics Gastroenterology and Hepatology Hepatitis C Virus Ribavirin Therapy Evaluate the Impact Persistently Normal |
| Content Type | Text |
| Resource Type | Article |
