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Brain Natriuretic Peptide and N-Terminal Pro-B-Type Natriuretic Peptide Show a Different Profile in Response to Acute Decompensated Heart Failure Treatment
| Content Provider | Scilit |
|---|---|
| Author | Somma, Salvatore Di Magrini, Laura Tabacco, Fabio Marino, Rossella Talucci, Veronica Marrocco, Francesca Cardelli, Patrizia Ferri, Enrico Pittoni, Valerio |
| Copyright Year | 2008 |
| Description | Journal: Congestive Heart Failure Brain natriuretic peptide (BNP) and N-terminal pro-B-type natriuretic peptide (NT-proBNP) are currently used for the diagnosis, prognosis, and therapeutic decision making in heart failure patients. The aim of the study was to compare BNP and NT-proBNP plasma concentration profiles in 42 patients with decompensated heart failure who underwent treatment in the emergency department. A significant decrease in both peptide concentrations fell beyond 24 hours of therapy. BNP concentration underwent a more responsive change from admission (-54.1%±8.6% at 72 hours and -57.4%±7.6% at discharge) than NT-proBNP concentration (-17.6%±5.4% at 72 hours and -18.6%±5.6% at discharge). Although BNP and NT-proBNP concentrations were highly correlated, no correlation in their variations was found, a finding that suggests a different kinetic behavior in response to treatment. Sequential measurements of BNP and NT-proBNP provide a reliable marker to confirm clinical improvement after 24 hours of treatment. BNP may show some advantages over NT-proBNP as a more sensitive marker of early stabilization in response to therapy. Congest Heart Fail. © 2008 Le Jacq |
| Related Links | http://onlinelibrary.wiley.com/doi/10.1111/j.1751-7133.2008.00002.x/pdf |
| Ending Page | 250 |
| Page Count | 6 |
| Starting Page | 245 |
| ISSN | 15275299 |
| e-ISSN | 17517133 |
| DOI | 10.1111/j.1751-7133.2008.00002.x |
| Journal | Congestive Heart Failure |
| Issue Number | 5 |
| Volume Number | 14 |
| Language | English |
| Publisher | Wiley-Blackwell |
| Publisher Date | 2008-10-21 |
| Access Restriction | Open |
| Subject Keyword | Journal: Congestive Heart Failure Cardiology and Cardiovascular Diseases Decision Making Nt Probnp |
| Content Type | Text |
| Resource Type | Article |
| Subject | Emergency Medicine Emergency Nursing Cardiology and Cardiovascular Medicine |
