NDLI: Activation of G Proteins Bidirectionally Affects Apoptosis of Cultured Cerebellar Granule Neurons

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Activation of G Proteins Bidirectionally Affects Apoptosis of Cultured Cerebellar Granule Neurons

Content Provider	Scilit
Author	Yan, Guang-Mei Lin, Sui-Zhen Irwin, Robert P. Paul, Steven M.
Copyright Year	2002
Description	Journal: Journal of Neurochemistry Cultured cerebellar granule neurons maintained in depolarizing concentrations of K+ (25 mM) and then switched to physiological concentrations of K+ (5 mM) undergo apoptosis. We now report that activation of specific G proteins robustly and bidirectionally affects apotosis of cultured rat cerebellar granule neurons. Stimulation of Gs with cholera toxin completely blocks apoptosis induced by nondepolarizing concentrations of K+, whereas stimulation of Go/Gi with the wasp venom peptide mastoparan induces apoptosis of cerebellar granule neurons even in high (depolarizing) concentrations of K+. Moreover, pretreatment of cerebellar granule neurons with cholera toxin attenuates neuronal death induced by mastoparan. By contrast, pertussis toxin, cell-permeable analogues of cyclic AMP, and activators of protein kinase A do not affect apoptosis of cultured cerebellar granule neurons. These data suggest that G proteins may function as key switches for controlling the programmed death of mammalian neurons, especially in the developing CNS.
Related Links	http://onlinelibrary.wiley.com/doi/10.1046/j.1471-4159.1995.65062425.x/pdf
Ending Page	2431
Page Count	7
Starting Page	2425
e-ISSN	14714159
DOI	10.1046/j.1471-4159.1995.65062425.x
Journal	Journal of Neurochemistry
Issue Number	6
Volume Number	65
Language	English
Publisher	Wiley-Blackwell
Publisher Date	2002-11-23
Access Restriction	Open
Subject Keyword	Journal: Journal of Neurochemistry Programmed Cell Death Cerebellar Granule Neurons
Content Type	Text
Resource Type	Article

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