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Neosurugatoxin, a Specific Antagonist of Nicotinic Acetylcholine Receptors
| Content Provider | Scilit |
|---|---|
| Author | Hayashi, E. Isogai, M. Kagawa, Y. Takayanagi, N. Yamada, S. |
| Copyright Year | 1984 |
| Description | Journal: Journal of Neurochemistry Neosurugatoxin (NSTX) (3 nM-30 nM), recently isolated from the Japanese ivory mollusc (Babylonia japonica) exerted a potent antinicotinic action in the isolated guinea pig ileum. Specific [3H]nicotine binding to rat forebrain membranes was saturable, reversible, and of high affinity. Nicotinic cholinergic agonists exhibited a markedly greater affinity for [3H]nicotine binding sites than a muscarinic agonist, oxotremorine. Although alpha-bungarotoxin had no effect on [3H]nicotine binding, low concentrations (1 nM-1 microM) of NSTX inhibited [3H]nicotine binding in the forebrain membranes and its IC50 value was 69 +/- 6 nM. On the other hand, NSTX did not affect muscarinic receptor binding in the brain. These data indicate that NSTX may be of appreciable interest as a neurotoxin with a selective affinity for ganglionic nicotinic receptors. |
| Related Links | http://onlinelibrary.wiley.com/doi/10.1111/j.1471-4159.1984.tb02817.x/pdf |
| Ending Page | 1494 |
| Page Count | 4 |
| Starting Page | 1491 |
| e-ISSN | 14714159 |
| DOI | 10.1111/j.1471-4159.1984.tb02817.x |
| Journal | Journal of Neurochemistry |
| Issue Number | 5 |
| Volume Number | 42 |
| Language | English |
| Publisher | Wiley-Blackwell |
| Publisher Date | 1984-05-01 |
| Access Restriction | Open |
| Subject Keyword | Journal: Journal of Neurochemistry Nicotinic Receptors [3h]‐nicotine Binding |
| Content Type | Text |
| Resource Type | Article |
