Loading...
Please wait, while we are loading the content...
Similar Documents
Inbred C57BL/6J and DBA/2J Mouse Strains Exhibit Constitutive Differences in Regional Brain Fatty Acid Composition
| Content Provider | Scilit |
|---|---|
| Author | McNamara, Robert K. Able, Jessica Jandacek, Ronald Rider, Therese Tso, Patrick |
| Copyright Year | 2008 |
| Description | Journal: Lipids Major behavioral and neurochemical features observed between inbred C57BL/6 and DBA/2 mouse strains can be reproduced within rodent strains following dietary-induced reductions in brain docosahexaenoic acid (DHA, 22:6n-3) composition. It was therefore hypothesized that C57BL/6 and DBA/2 mice exhibit constitutive differences in brain DHA composition that are independent of diet. To test this, adult C57BL/6J and DBA/2J prefrontal cortex, hippocampus, ventral striatum, and midbrain fatty acid composition was determined by gas chromatography. After correction for multiple comparisons, C57BL/6J mice exhibited significantly lower DHA composition in the hippocampus and ventral striatum, but not prefrontal cortex or midbrain, and significantly greater regional arachidonic acid (ARA, 20:4n-6):DHA ratios, relative to DBA/2J mice. C57BL/6J mice also exhibited significantly lower regional adrenic acid (ADA, 22:4n-6) composition, and a significantly smaller ADA:ARA ratio, relative to DBA/2J mice. C57BL/6J mice exhibited significantly smaller oleic acid:stearic acid ratio in the hippocampus and ventral striatum relative to DBA/2J mice. Among all mice, DHA composition was positively correlated with the ADA:ARA ratio and inversely correlated with the oleic acid:stearic acid ratio. These data demonstrate that inbred C57BL/6J and DBA/2J mouse strains exhibit constitutive and region-specific differences in fatty acid composition independent of diet, and suggest that heritable genetic factors are an important determinant of central fatty acid composition. |
| Ending Page | 8 |
| Starting Page | 1 |
| ISSN | 00221295 |
| e-ISSN | 15589307 |
| DOI | 10.1007/s11745-008-3244-8 |
| Journal | Lipids |
| Issue Number | 1 |
| Volume Number | 44 |
| Language | English |
| Publisher | Wiley-Blackwell |
| Publisher Date | 2008-10-16 |
| Access Restriction | Open |
| Subject Keyword | Journal: Lipids Endocrinology and Metabolism Composition Independent Independent of Diet Strains Exhibit Constitutive Dba/2j Mouse Inbred C57bl/6j |
| Content Type | Text |
| Resource Type | Article |
| Subject | Physiology |
