Prediagnosis body mass index and waist-hip circumference ratio in association with colorectal cancer survival

Content Provider	Scilit
Author	Wang, Nan Khankari, Nikhil K. Cai, Hui Li, Hong-Lan Yang, Gong Gao, Yu-Tang Xiang, Yong-Bing Shu, Xiao-Ou Zheng, Wei
Copyright Year	2016
Description	Journal: International Journal of Cancer The association of obesity on survival among patients with colorectal cancer (CRC) has not been well characterized. We investigated the association of prediagnostic body mass index (BMI)/waist-hip ratio (WHR) and total/cause-specific mortality in CRC patients. Our study included 1,452 patients who participated in two large cohort studies and were diagnosed with CRC during follow-up period. Participants were measured for anthropometrics and interviewed to collect relevant information at baseline, prior to any cancer diagnosis. Data on site-specific cancer incidence and cause-specific mortality were obtained via in-person surveys and annual record linkage with cancer and vital statistics registries. Cox proportional hazard models were used to evaluate the associations of BMI and WHR with survival. A total of 547 participants died during the follow-up period, including 499 who died of CRC. Relative to normal BMI (18.5 to <25.0 kg/m2 ), obesity (BMI ≥ 30 kg/m2 ) was associated with increased mortality resulting from all causes [hazard ratio (HR) = 1.5, 95% confidence interval (CI): 1.1-2.1] and CRC (HR = 1.5, 95% CI: 1.1-2.1). Elevated risk of death was also found among underweight patients (BMI < 18.5 kg/m2 ), although not all risk estimates were statistically significant. Overweight BMI (25.0 to <30.0 kg/m2 ) was not associated with risk of death among CRC patients, nor was WHR. In conclusion, prediagnostic BMI was associated with survival among CRC patients following a U-shape pattern; obesity was associated with high mortality after CRC diagnosis. These findings provide support for maintaining healthy weight to improve the survival of CRC patients.
Related Links	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5531439/pdf
Ending Page	301
Page Count	10
Starting Page	292
e-ISSN	10970215
DOI	10.1002/ijc.30459
Journal	International Journal of Cancer
Issue Number	2
Volume Number	140
Language	English
Publisher	Wiley-Blackwell
Publisher Date	2016-10-24
Access Restriction	Open
Subject Keyword	Journal: International Journal of Cancer Public, Environmental and Occupational Health Body Mass Index Colorectal Cancer Waist-hip Ratio
Content Type	Text
Resource Type	Article