NDLI: Mouse Immunoglobulin Subclasses: Cyanogen Bromide Fragments and Partial Sequence of a gamma1 Chain

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Mouse Immunoglobulin Subclasses: Cyanogen Bromide Fragments and Partial Sequence of a gamma1 Chain

Content Provider	Scilit
Author	Adetugbo, Kayode Milstein, Cesar Poskus, Edgardo Svasti, Jisnuson
Copyright Year	1975
Description	Journal: Journal of Biological Inorganic Chemistry The purification and characterisation of all the cyanogen bromide fragments of MOPC 21 heavy (γ1) chain is described. The ten BrCN fragments account for the whole chain. Four of these fragments have been used to establish the sequence of the C-terminal stretch (138 residues) that includes the entire CH3 and a part of the CH2 homology regions. A comparison of this sequence with homologous sequences is presented. Mouse γ1 and γ2 proteins differ much more than the γ subclasses in humans and in other species. The comparison further suggests that the four human γ subclasses and mouse γ1 have a common ancestor which differs from the mouse γ2 ancestor. Unlike other subclasses, mouse γ1 and γ2 genes have diverged before speciation.
Related Links	https://onlinelibrary.wiley.com/doi/pdf/10.1111/j.1432-1033.1975.tb02256.x
Ending Page	519
Page Count	17
Starting Page	503
ISSN	09498257
e-ISSN	14321327
DOI	10.1111/j.1432-1033.1975.tb02256.x
Journal	Journal of Biological Inorganic Chemistry
Issue Number	2
Volume Number	56
Language	English
Publisher	Wiley-Blackwell
Publisher Date	1975-08-01
Access Restriction	Open
Subject Keyword	Journal: Journal of Biological Inorganic Chemistry Biochemical Research
Content Type	Text
Resource Type	Article
Subject	Biochemistry Inorganic Chemistry

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