Loading...
Please wait, while we are loading the content...
Similar Documents
Polypharmacy, Drug-Drug Interactions, and Potentially Inappropriate Medications in Older Adults with Human Immunodeficiency Virus Infection
| Content Provider | Scilit |
|---|---|
| Author | Greene, Meredith Steinman, Michael A. McNicholl, Ian R. Valcour, Victor |
| Copyright Year | 2014 |
| Description | Journal: Journal of the American Geriatrics Society To describe the frequency of medication-related problems in older adults with human immunodeficiency virus (HIV) infection. Retrospective chart review. Community. HIV-positive individuals aged 60 and older and age- and sex-matched HIV-negative individuals. Total number of medications, potentially inappropriate medications (PIMs) according to the modified Beers Criteria, anticholinergic drug burden according to the Anticholinergic Risk Scale (ARS), and drug-drug interactions using the Lexi-Interact online drug interactions database. Of 89 HIV-positive participants, most were Caucasian (91%) and male (94%), with a median age of 64 (range 60-82). Common comorbidities included hyperlipidemia, hypertension, and depression. Participants were taking a median of 13 medications (range 2-38), of which only a median of four were antiretrovirals. At least one PIM was prescribed in 46 participants (52%). Sixty-two (70%) participants had at least one Category D (consider therapy modification) drug-drug interaction, and 10 (11%) had a Category X (avoid combination) interaction. One-third of these interactions were between two nonantiretroviral medications. Fifteen participants (17%) had an ARS score of 3 or greater. In contrast, HIV-negative participants were taking a median of six medications, 29% had at least one PIM, and 4% had an ARS score of 3 or greater (P < .05 for each comparison, except P = .07 for anticholinergic burden). HIV-positive older adults have a high frequency of medication-related problems, of which a large portion is due to medications used to treat comorbid diseases. These medication issues were substantially higher than HIV-negative participants. Attention to the principles of geriatric prescribing is needed as this population ages in order to minimize complications from multiple medication use. |
| Related Links | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4043391/pdf |
| Ending Page | 453 |
| Page Count | 7 |
| Starting Page | 447 |
| e-ISSN | 15325415 |
| DOI | 10.1111/jgs.12695 |
| Journal | Journal of the American Geriatrics Society |
| Issue Number | 3 |
| Volume Number | 62 |
| Language | English |
| Publisher | Wiley-Blackwell |
| Publisher Date | 2014-02-27 |
| Access Restriction | Open |
| Subject Keyword | Journal: Journal of the American Geriatrics Society Drug Interactions Inappropriate Prescribing |
| Content Type | Text |
| Resource Type | Article |
