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Pd$ ^{II}$ ‐Catalyzed Enantioselective C(sp$ ^{3}$ )−H Activation/Cross‐Coupling Reactions of Free Carboxylic Acids
| Content Provider | Scilit |
|---|---|
| Author | Hu, Liang Shen, Peng‐Xiang Shao, Qian Hong, Kai Qiao, Jennifer X. Yu, Jin‐Quan |
| Copyright Year | 2018 |
| Description | Journal: Angewandte Chemie International Edition Pd(II)‐catalyzed enantioselective C(sp3)−H cross‐coupling of free carboxylic acids with organoborons has been realized using either mono‐protected amino acid (MPAA) ligands or mono‐protected aminoethyl amine (MPAAM) ligands. A diverse range of aryl‐ and vinyl‐boron reagents can be used as coupling partners to provide chiral carboxylic acids. This reaction provides an alternative approach to the enantioselective synthesis of cyclopropanecarboxylic acids and cyclobutanecarboxylic acids containing α‐chiral tertiary and quaternary stereocenters. The utility of this reaction was further demonstrated by converting the carboxylic acid into cyclopropyl amine without loss of optical activity. |
| Related Links | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6641982/pdf |
| Ending Page | 2138 |
| Page Count | 5 |
| Starting Page | 2134 |
| ISSN | 14337851 |
| e-ISSN | 15213773 |
| DOI | 10.1002/anie.201813055 |
| Journal | Angewandte Chemie International Edition |
| Issue Number | 7 |
| Volume Number | 58 |
| Language | English |
| Publisher | Wiley-Blackwell |
| Publisher Date | 2018-12-10 |
| Access Restriction | Open |
| Subject Keyword | Journal: Angewandte Chemie International Edition Organic Chemistry C-h Activation |
| Content Type | Text |
| Resource Type | Article |
| Subject | Chemistry Catalysis |
