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Plasma Amino Acid Profiling in Major Depressive Disorder Treated With Selective Serotonin Reuptake Inhibitors

Content Provider	Scilit
Author	Woo, Hye-In Chun, Mi-Ryung Yang, Jeong-Soo Lim, Shinn-Won Kim, Min-Ji Kim, Seon-Woo Myung, Woo-Jae Kim, Doh-Kwan Lee, Soo-Youn
Copyright Year	2015
Description	Journal: CNS neuroscience & therapeutics Amino acids are important body metabolites and seem to be helpful for understanding pathogenesis and predicting therapeutic response in major depressive disorder (MDD). We performed amino acid profiling to discover potential biomarkers in major depressive patients treated with selective serotonin reuptake inhibitors (SSRIs).Amino acid profiling using aTRAQ™ kits for Amino Acid Analysis in Physiological Fluids on a liquid chromatography-tandem mass spectrometry (LC-MS/MS) system was performed on 158 specimens at baseline and at 6 weeks after the initiation of SSRI treatment for 68 patients with MDD and from 22 healthy controls.Baseline alpha-aminobutyric acid (ABA) discriminated the patients according to the therapeutic response. Plasma glutamic acid concentration and glutamine/glutamic acid ratio were different between before and after SSRI treatment only in the response group. Comparing patients with MDD with healthy controls, alterations of ten amino acids, including alanine, beta-alanine, beta-aminoisobutyric acid, cystathionine, ethanolamine, glutamic acid, homocystine, methionine, O-phospho-L-serine, and sarcosine, were observed in MDD.Metabolism of amino acids, including ABA and glutamic acid, has the potential to contribute to understandings of pathogenesis and predictions of therapeutic response in MDD.
Related Links	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6495833/pdf
Ending Page	424
Page Count	8
Starting Page	417
e-ISSN	17555949
DOI	10.1111/cns.12372
Journal	CNS neuroscience & therapeutics
Issue Number	5
Volume Number	21
Language	English
Publisher	Wiley-Blackwell
Publisher Date	2015-01-22
Access Restriction	Open
Subject Keyword	Journal: CNS neuroscience & therapeutics Psychiatry and Mental Health Alpha-aminobutyric Acid Selective Serotonin Reuptake Inhibitor
Content Type	Text
Resource Type	Article

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