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Distribution of blood flow velocity in the normal aorta: Effect of age and gender
| Content Provider | Scilit |
|---|---|
| Author | Garcia, Julio van der Palen, Roel L. F. Bollache, Emilie Jarvis, Kelly Rose, Michael J. Barker, Alex J. Collins, Jeremy D. Carr, James C. Robinson, Joshua Rigsby, Cynthia K. Markl, Michael |
| Copyright Year | 2017 |
| Description | Journal: Journal of Magnetic Resonance Imaging (JMRI) To apply flow distribution analysis in the entire aorta across a wide age range from pediatric to adult subjects. In all, 98 healthy subjects (age 9-78 years, 41 women) underwent 4D flow MRI at 1.5T and 3T for the assessment of 3D blood flow in the thoracic aorta. Subjects were categorized into age groups: group 1 (n = 9, 5 women): 9-15 years; group 2 (n = 13, 8 women): 16-20 years; group 3 (n = 27, 14 women): 21-39 years; group 4 (n = 40, 11 women): 40-59 years; group 5 (n = 9, 3 women): >60 years. Data analysis included the 3D segmentation of the aorta, aortic valve peak velocity, mid-ascending aortic diameter, and calculation of flow velocity distribution descriptors (mean, median, standard deviation, incidence of velocities >1 m/s, skewness, and kurtosis of aortic velocity magnitude). Ascending aortic diameter was normalized by body surface area. Age was significantly associated with normalized aortic diameter (R = 0.73, P < 0.001), skewness (R = 0.76, P < 0.001), and kurtosis (R = 0.74, P < 0.001), all adjusted by heart rate. Aortic peak velocity and velocity distribution descriptors, adjusted by heart rate, were significantly different between age groups (P < 0.001, analysis of covariance). Skewness and kurtosis significantly increased (P < 0.001) during adulthood (>40 years) as compared with childhood (<21 years). Men and women revealed significant differences (P ≤ 0.05) for peak velocity, incidence, mean, median, standard deviation, and skewness, all adjusted by heart rate. Aortic hemodynamics significantly change with age and gender, indicating the importance of age- and gender-matched control cohorts for the assessment of the impact of cardiovascular disease on aortic blood flow. 3 Technical Efficacy: Stage 5 J. Magn. Reson. Imaging 2018;47:487-498. |
| Related Links | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5702593/pdf |
| Ending Page | 498 |
| Page Count | 12 |
| Starting Page | 487 |
| e-ISSN | 15222586 |
| DOI | 10.1002/jmri.25773 |
| Journal | Journal of Magnetic Resonance Imaging (JMRI) |
| Issue Number | 2 |
| Volume Number | 47 |
| Language | English |
| Publisher | Wiley-Blackwell |
| Publisher Date | 2017-05-26 |
| Access Restriction | Open |
| Subject Keyword | Journal: Journal of Magnetic Resonance Imaging (JMRI) Radiology, Nuclear Medicine and Imaging 4d Flow Mri Heart Valve Disease |
| Content Type | Text |
| Resource Type | Article |
