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A Monoclonal Antibody Defining Human B Cell Differentiation Antigen (HLB-1 Antigen)
| Content Provider | Scilit |
|---|---|
| Author | Kasai, Kiyoshi Koshiba, Hirofumi Ishii, Yoshifumi Kikuchi, Koukichi |
| Copyright Year | 1983 |
| Description | Journal: Microbiology and Immunology A new monoclonal antibody specific for human B cell differentiation antigen (HLB-1) is produced by a hybridoma established by fusion of splenocytes of mice immunized with the Epstein-Barr virus (EBV)-transformed peripheral B cell line, RPMI-8057. This monoclonal, antibody designated anti-HLB-1 monoclonal antibody (anti-HLB-1), reacted with surface immunoglobulin (sIg)-positive B cells of normal peripheral blood and lymphoid tissues and sIg-positive leukemic cells. The cells of T cell leukemia, non-T non-B acute lymphoblastic leukemia (ALL) and nonlymphoid leukemia were HLB-1 negative. These data were further confirmed by studying a panel of cultured human hematopoietic cell lines. Anti-HLB-1 reacted with B cell lines derived from pre-B, Burkitt's lymphoma, B cell type ALL and EBV-transformed peripheral B cells. Anti-HLB-1 was reactive with only one of three human myeloma cell lines, and with none of the T cell, myeloid and non-T non-B ALL cell lines. This newly defined HLB-1 antigen is different from other conventional human B cell markers such as sIg, Ia antigens, and receptors for the Fc portion of Ig and complement C3. |
| Ending Page | 64 |
| Starting Page | 51 |
| ISSN | 2573508X |
| e-ISSN | 13480421 |
| DOI | 10.1111/j.1348-0421.1983.tb03567.x |
| Journal | Microbiology and Immunology |
| Issue Number | 1 |
| Volume Number | 27 |
| Language | English |
| Publisher | Wiley-Blackwell |
| Publisher Date | 1983-01-01 |
| Access Restriction | Open |
| Subject Keyword | Journal: Microbiology and Immunology Monoclonal Antibody |
| Content Type | Text |
| Resource Type | Article |
| Subject | Virology Immunology Microbiology |
