NDLI: The von Hippel-Lindau gene

Please wait, while we are loading the content...

The von Hippel-Lindau gene

Content Provider	Scilit
Author	Clark, Peter E. Cookson, Michael S.
Copyright Year	2008
Description	Journal: Cancer Mutations or aberrations of the von Hippel‐Lindau gene are responsible for the hereditary neoplastic syndrome that bears the same name, as well as for the majority of sporadic clear cell renal cell carcinomas. The discovery of this gene and subsequent clarification of its mechanism of action have led to a series of targeted treatments for advanced kidney cancer and have dramatically changed how we manage this disease. The discovery of the VHL gene is a prime example of how discoveries at the bench can inform and revolutionize therapeutics at the bedside. In this review, the authors trace this illuminating tale, from the cloning of the VHL gene, to elucidating its biologic function, to the development of novel therapeutics that have dramatically changed the paradigm of managing advanced renal cell carcinoma. Cancer 2008;113(7 suppl):1768–78. © 2008 American Cancer Society.
Related Links	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2963103/pdf
Ending Page	1778
Page Count	11
Starting Page	1768
e-ISSN	10970142
DOI	10.1002/cncr.23645
Journal	Cancer
Issue Number	S7
Volume Number	113
Language	English
Publisher	Wiley-Blackwell
Publisher Date	2008-09-17
Access Restriction	Open
Subject Keyword	Journal: Cancer Von Hippel‐lindau Gene Renal Cell Carcinoma Clear Cell Renal Cell Carcinoma Kidney Cancer
Content Type	Text

Sl.	Authority	Responsibilities	Communication Details
1	Ministry of Education (GoI), Department of Higher Education	Sanctioning Authority	https://www.education.gov.in/ict-initiatives
2	Indian Institute of Technology Kharagpur	Host Institute of the Project: The host institute of the project is responsible for providing infrastructure support and hosting the project	https://www.iitkgp.ac.in
3	National Digital Library of India Office, Indian Institute of Technology Kharagpur	The administrative and infrastructural headquarters of the project	Dr. B. Sutradhar bsutra@ndl.gov.in
4	Project PI / Joint PI	Principal Investigator and Joint Principal Investigators of the project	Dr. B. Sutradhar bsutra@ndl.gov.in Prof. Saswat Chakrabarti will be added soon
5	Website/Portal (Helpdesk)	Queries regarding NDLI and its services	support@ndl.gov.in
6	Contents and Copyright Issues	Queries related to content curation and copyright issues	content@ndl.gov.in
7	National Digital Library of India Club (NDLI Club)	Queries related to NDLI Club formation, support, user awareness program, seminar/symposium, collaboration, social media, promotion, and outreach	clubsupport@ndl.gov.in
8	Digital Preservation Centre (DPC)	Assistance with digitizing and archiving copyright-free printed books	dpc@ndl.gov.in
9	IDR Setup or Support	Queries related to establishment and support of Institutional Digital Repository (IDR) and IDR workshops	idr@ndl.gov.in