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The Clinical Impact of [$ ^{68}$ Ga]‐DOTATATE PET/CT for the Diagnosis and Management of Ectopic Adrenocorticotropic Hormone – Secreting Tumours
| Content Provider | Scilit |
|---|---|
| Author | Wannachalee, Taweesak Turcu, Adina F. Bancos, Irina Habra, Mouhammed Amir Avram, Anca M. Chuang, Hubert H. Waguespack, Steven G. Auchus, Richard J. |
| Copyright Year | 2019 |
| Description | Journal: Clinical endocrinology Localization of ectopic ACTH-secreting tumours causing Cushing syndrome (ECS) is essential for clinical management, yet often difficult. [68 Ga]-DOTATATE PET/CT ([68 Ga]-DOTA-(Tyr3 )-octreotate)] is an FDA-approved high-resolution diagnostic tool for imaging neuroendocrine tumours. Data on the clinical utility of [68 Ga]-DOTATATE in patients with ECS, however, are scarce. The objectives of this study were to determine the efficacy for ECS localization and the clinical benefit of [68 Ga]-DOTATATE imaging. We conducted a retrospective review of all cases with ECS evaluated with [68 Ga]-DOTATATE from November 2016 through October 2018 at three referral centres. The clinical benefit of [68 Ga]-DOTATATE was based on detection of new tumours and resultant changes in management. Over the study period, 28 patients with ECS underwent [68 Ga]-DOTATATE: 17 for identification of the primary tumour and 11 during follow-up. [68 Ga]-DOTATATE identified the suspected primary ECS in 11/17 patients (65%). Of these, nine patients underwent surgery: eight with confirmed ECS (5 bronchial, 1 thymic, 1 pancreatic and 1 metastatic neuroendocrine tumour of unknown primary origin) and one patient with a false-positive scan (adrenal gland). Of the 11 patients with ECS who underwent [68 Ga]-DOTATATE evaluation during follow-up, the study led to changes in clinical management in 7/11 (64%) patients. [68 Ga]-DOTATATE is sensitive in detecting primary and metastatic ECS, often identifies occult tumours after conventional imaging, and impacts clinical care in the majority of patients. |
| Related Links | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6689243/pdf |
| Ending Page | 294 |
| Page Count | 7 |
| Starting Page | 288 |
| e-ISSN | 13652265 |
| DOI | 10.1111/cen.14008 |
| Journal | Clinical endocrinology |
| Issue Number | 2 |
| Volume Number | 91 |
| Language | English |
| Publisher | Wiley-Blackwell |
| Publisher Date | 2019-05-16 |
| Access Restriction | Open |
| Subject Keyword | Journal: Clinical endocrinology Endocrinology and Metabolism Cushing Syndrome [68ga]-dotatate Pet Ectopic Acth Secretion Somatostatin Receptor Tumour Localization |
| Content Type | Text |
| Resource Type | Article |
