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Free-breathing post-contrast three-dimensional $T_{1}$ mapping: Volumetric assessment of myocardial $T_{1}$ values
| Content Provider | Scilit |
|---|---|
| Author | Weingärtner, Sebastian Akçakaya, Mehmet Roujol, Sébastien Basha, Tamer Stehning, Christian Kissinger, Kraig V. Goddu, Beth Berg, Sophie Manning, Warren J. Nezafat, Reza |
| Copyright Year | 2014 |
| Description | Journal: Magnetic Resonance in Medicine To develop a three-dimensional (3D) free-breathing myocardial T1 mapping sequence for assessment of left ventricle diffuse fibrosis after contrast administration. In the proposed sequence, multiple 3D inversion recovery images are acquired in an interleaved manner. A mixed prospective/retrospective navigator scheme is used to obtain the 3D Cartesian k-space data with fully sampled center and randomly undersampled outer k-space. The resulting undersampled 3D k-space data are then reconstructed using compressed sensing. Subsequently, T1 maps are generated by voxel-wise curve fitting of the individual interleaved images. In a phantom study, the accuracy of the 3D sequence was evaluated against two-dimensional (2D) modified Look-Locker inversion recovery (MOLLI) and spin-echo sequences. In vivo T1 times of the proposed method were compared with 2D multislice MOLLI T1 mapping. Subsequently, the feasibility of high-resolution 3D T1 mapping with spatial resolution of 1.7 × 1.7 × 4 mm(3) was demonstrated. The proposed method shows good agreement with 2D MOLLI and the spin-echo reference in phantom. No significant difference was found in the in vivo T1 times estimated using the proposed sequence and the 2D MOLLI technique (myocardium, 330 ± 66 ms versus 319 ± 93 ms; blood pools, 211 ± 68 ms versus 210 ± 98 ms). However, improved homogeneity, as measured using standard deviation of the T1 signal, was observed in the 3D T1 maps. The proposed sequence enables high-resolution 3D T1 mapping after contrast injection during free-breathing with volumetric left ventricle coverage. |
| Related Links | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4122651/pdf |
| Ending Page | 222 |
| Page Count | 9 |
| Starting Page | 214 |
| e-ISSN | 15222594 |
| DOI | 10.1002/mrm.25124 |
| Journal | Magnetic Resonance in Medicine |
| Issue Number | 1 |
| Volume Number | 73 |
| Language | English |
| Publisher | Wiley-Blackwell |
| Publisher Date | 2014-02-05 |
| Access Restriction | Open |
| Subject Keyword | Journal: Magnetic Resonance in Medicine Radiology, Nuclear Medicine and Imaging Diffused Fibrosis Myocardial T1 Mapping Navigator Gating Quantitative Cardiac Mri |
| Content Type | Text |
| Resource Type | Article |
