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MRI-based quantitative susceptibility mapping (QSM) and R2* mapping of liver iron overload: Comparison with SQUID-based biomagnetic liver susceptometry
| Content Provider | Scilit |
|---|---|
| Author | Sharma, Samir D. Fischer, Roland Schoennagel, Bjoern P. Nielsen, Peter Kooijman, Hendrik Yamamura, Jin Adam, Gerhard Bannas, Peter Hernando, Diego Reeder, Scott B. |
| Copyright Year | 2016 |
| Description | Journal: Magnetic Resonance in Medicine We aimed to determine the agreement between quantitative susceptibility mapping (QSM)-based biomagnetic liver susceptometry (BLS) and confounder-corrected R2* mapping with superconducting quantum interference device (SQUID)-based biomagnetic liver susceptometry in patients with liver iron overload. Data were acquired from two healthy controls and 22 patients undergoing MRI and SQUID-BLS as part of routine monitoring for iron overload. Magnetic resonance imaging was performed on a 3T system using a three-dimensional multi-echo gradient-echo acquisition. Both magnetic susceptibility and R2* of the liver were estimated from this acquisition. Linear regression was used to compare estimates of QSM-BLS and R2* to SQUID-BLS. Both QSM-BLS and confounder-corrected R2* were sensitive to the presence of iron in the liver. Linear regression between QSM-BLS and SQUID-BLS demonstrated the following relationship: QSM-BLS = (-0.22 ± 0.11) + (0.49 ± 0.05) · SQUID-BLS with r2 = 0.88. The coefficient of determination between liver R2* and SQUID-BLS was also r2 = 0.88. We determined a strong correlation between both QSM-BLS and confounder-corrected R2* to SQUID-BLS. This study demonstrates the feasibility of QSM-BLS and confounder-corrected R2* for assessing liver iron overload, particularly when SQUID systems are not accessible. Magn Reson Med 78:264-270, 2017. © 2016 International Society for Magnetic Resonance in Medicine. |
| Related Links | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5303570/pdf |
| Ending Page | 270 |
| Page Count | 7 |
| Starting Page | 264 |
| e-ISSN | 15222594 |
| DOI | 10.1002/mrm.26358 |
| Journal | Magnetic Resonance in Medicine |
| Issue Number | 1 |
| Volume Number | 78 |
| Language | English |
| Publisher | Wiley-Blackwell |
| Publisher Date | 2016-08-11 |
| Access Restriction | Open |
| Subject Keyword | Journal: Magnetic Resonance in Medicine Radiology, Nuclear Medicine and Imaging R2* Mapping; Squid Liver Iron Overload Magnetic Susceptibility Quantitative Susceptibility Mapping |
| Content Type | Text |
| Resource Type | Article |
