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Low serum interleukin-17 is associated with preterm delivery
| Content Provider | Scilit |
|---|---|
| Author | Hee, Lene Kirkegaard, Ida Vogel, Ida Thorsen, Poul Skogstrand, Kristin Hougaard, David M. Uldbjerg, Niels Sandager, Puk |
| Copyright Year | 2010 |
| Description | Journal: Acta Obstetricia et Gynecologica Scandinavica To study maternal serum interleukin-17 (IL-17) during normal pregnancy and evaluate the association with preterm delivery. Prospective study. Aarhus University Hospital, Denmark. Three cohorts: (a) low-risk cohort of 1,069 women who had serum drawn in weeks 12 and 19, (b) subgroup of the low-risk cohort, consisting of 40 women, who had serum drawn at 12, 19, 26, 33 and 39 weeks of gestation and (c) a symptomatic cohort of 93 women admitted with symptoms of preterm delivery at a gestational age of 24(+ 0) weeks to 33(+ 6) weeks. Serum IL-17 determined by an in-house developed multiplex sandwich immunoassay. Preterm delivery <37(+0) weeks gestation. Serum IL-17 did not change during normal pregnancy. At admission to hospital, women with preterm contractions had significantly decreased serum IL-17 as compared with normal pregnancies (median <4 [interquartile ranges, IQR, <4-10 pg/ml] vs. 174 pg/ml [IQR, 92 - 485 pg/ml]); this difference was enhanced and highly significant for women delivering preterm versus term (median <4 [IQR, <4-7.9 pg/ml] vs. median 6.0 [IQR, <4-221 pg/ml]; p-value 0.03). Serum IL-17 was also lower in women with preterm prelabor rupture of membranes. A slightly, but not statistically significant decrease was found in weeks 12 and 19 in low-risk women who subsequently delivered preterm. Maternal serum IL-17 may be involved in preterm delivery. |
| Related Links | http://onlinelibrary.wiley.com/doi/10.1111/j.1600-0412.2010.01017.x/pdf |
| Ending Page | 96 |
| Page Count | 5 |
| Starting Page | 92 |
| ISSN | 00016349 |
| e-ISSN | 16000412 |
| DOI | 10.1111/j.1600-0412.2010.01017.x |
| Journal | Acta Obstetricia et Gynecologica Scandinavica |
| Issue Number | 1 |
| Volume Number | 90 |
| Language | English |
| Publisher | Wiley-Blackwell |
| Publisher Date | 2010-11-26 |
| Access Restriction | Open |
| Subject Keyword | Journal: Acta Obstetricia et Gynecologica Scandinavica Obstetrics and Gynecology Spontaneous Preterm Delivery |
| Content Type | Text |
| Resource Type | Article |
| Subject | Obstetrics and Gynecology |
