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Clickable amphiphilic triblock copolymers
| Content Provider | Scilit |
|---|---|
| Author | Isaacman, Michael J. Barron, Kathryn A. Theogarajan, Luke S. |
| Copyright Year | 2012 |
| Description | Journal: Journal of Polymer Science Part A: Polymer Chemistry Amphiphilic polymers have recently garnered much attention due to their potential use in drug-delivery and other biomedical applications. A modular synthesis of these polymers is extremely desirable since it offers precise individual block characterization and increased yields. We present here for the first time a modular synthesis of poly(oxazoline)-poly(siloxane)-poly(oxazoline) block copolymers that have been clicked together using the copper-catalyzed azide-alkyne cycloaddition reaction. Various click methodologies for the synthesis of these polymers have been carefully evaluated and optimized. The approach using copper nanoparticles was found to be the most optimal among the methods evaluated. Furthermore, these results were extended to allow for a reactive Si-H group-based siloxane middle block to be successfully clicked. This enables the design of more complex amphiphilic block copolymers that have additional functionality, such as stimuli responsiveness, to be synthesized via a simple hydrosilylation reaction. |
| Related Links | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3478948/pdf |
| Ending Page | 2329 |
| Page Count | 11 |
| Starting Page | 2319 |
| ISSN | 0887624X |
| e-ISSN | 10990518 |
| DOI | 10.1002/pola.25989 |
| Journal | Journal of Polymer Science Part A: Polymer Chemistry |
| Issue Number | 12 |
| Volume Number | 50 |
| Language | English |
| Publisher | Wiley-Blackwell |
| Publisher Date | 2012-03-05 |
| Access Restriction | Open |
| Subject Keyword | Journal: Journal of Polymer Science Part A: Polymer Chemistry Triblock Copolymers |
| Content Type | Text |
| Resource Type | Article |
| Subject | Organic Chemistry Materials Chemistry Polymers and Plastics |
