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Antral gastrin cell hyperfunction and Helicobacter pylori infection
| Content Provider | Scilit |
|---|---|
| Author | D'Ambra, G. Annibale, B. Rindi, G. Marignani, M. Solcia, E. Bordi, C. Fave, G. Delle |
| Copyright Year | 1996 |
| Description | Journal: Alimentary Pharmacology & Therapeutics Background: Antral gastrin cell hyperfunction (AGCH), is a rare cause of duodenal ulcer associated with non‐tumour hypergastrinaemia and acid hypersecretion. Aim: To investigate the role of Helicobacter pylori in AGCH. Patients: Twelve AGCH patients and eight H. pylori‐positive non‐hypergastrinaemic duodenal ulcer patients were compared. Methods: Basal and peak acid outputs, gastrin‐stimulation (meal and bombesin) tests, and immunohistochemistry for antral G and D cells were performed. One year after H. pylori eradication, six AGCH patients were again investigated with the same tests. Results: Significantly more basal, and stimulated gastrin and acid secretion, were found in AGCH compared to the H. pylori‐positive duodenal ulcer patients (P<0.01). G cell counts were significantly higher in AGCH than in duodenal ulcer patients (118.8, range 58–192.4, vs. 86.1, range 49–184; P<0.05), and the resulting G/D cell ratio was also higher in AGCH patients (4.2, range 2.6–5.6, vs. 3.3, range 1.9–4.3; P<0.05). H. pylori was present in the gastric mucosa of all 12 AGCH patients. Cure of infection in six AGCH individuals resulted in marked a decrease of gastrin levels associated with a significant (23.7%; P<0.05) decrease of G cell count and an increase (12%; P<0.05) of D cell count. Conclusions: The results indicate that AGCH may result from H. pylori overstimulation of gastrin cell function in patients with some presently undefined, familial predisposition and that an imbalance of the G/D cell ratio may have a role in the genesis of hypergastrinaemia. |
| Related Links | https://onlinelibrary.wiley.com/doi/pdf/10.1046/j.1365-2036.1996.31173000.x |
| Ending Page | 615 |
| Page Count | 9 |
| Starting Page | 607 |
| e-ISSN | 13652036 |
| DOI | 10.1046/j.1365-2036.1996.31173000.x |
| Journal | Alimentary Pharmacology & Therapeutics |
| Issue Number | 4 |
| Volume Number | 10 |
| Language | English |
| Publisher | Wiley-Blackwell |
| Publisher Date | 1996-08-01 |
| Access Restriction | Open |
| Subject Keyword | Journal: Alimentary Pharmacology & Therapeutics Gastroenterology and Hepatology |
| Content Type | Text |
| Resource Type | Article |
