NDLI: Future prospects for CD8$ ^{+}$ regulatory T cells in immune tolerance

Content Provider	Scilit
Author	Flippe, Léa Bézie, Séverine Anegon, Ignacio Guillonneau, Carole
Copyright Year	2019
Description	Journal: Immunological Reviews CD8+ Tregs have been long described and significant progresses have been made about their phenotype, their functional mechanisms, and their suppressive ability compared to conventional CD4+ Tregs. They are now at the dawn of their clinical use. In this review, we will summarize their phenotypic characteristics, their mechanisms of action, the similarities, differences and synergies between CD8+ and CD4+ Tregs, and we will discuss the biology, development and induction of CD8+ Tregs, their manufacturing for clinical use, considering open questions/uncertainties and future technically accessible improvements notably through genetic modifications.
Related Links	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7027528/pdf
Ending Page	224
Page Count	16
Starting Page	209
e-ISSN	1600065X
DOI	10.1111/imr.12812
Journal	Immunological Reviews
Issue Number	1
Volume Number	292
Language	English
Publisher	Wiley-Blackwell
Publisher Date	2019-10-08
Access Restriction	Open
Subject Keyword	Journal: Immunological Reviews Research and Experimental Medicine Cd8+ Treg
Content Type	Text
Resource Type	Article

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Future prospects for CD8$ ^{+}$ regulatory T cells in immune tolerance