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Impact of depth and extent of lymphovascular space invasion on lymph node metastasis and recurrence patterns in endometrial cancer
| Content Provider | Scilit |
|---|---|
| Author | Matsuo, Koji Garcia-Sayre, Jocelyn Medeiros, Fabiola Casabar, Jennifer K. Machida, Hiroko Moeini, Aida Roman, Lynda D. |
| Copyright Year | 2015 |
| Description | Journal: Journal of Surgical Oncology To determine the significance of depth and extent of lymphovascular space invasion (LVSI) on lymph node metastasis and recurrence in endometrial cancer. A case-control study was conducted to examine LVSI-positive (n=70) and LVSI-negative (n=641) stage I–III endometrial cancer cases that underwent hysterectomy-based surgical staging. The risk of lymph node metastasis and distant recurrence was estimated based on LVSI patterns. In multivariate analysis, deep (>50% invasion), and extensive (≥7 foci/slide) LVSI patterns had a significantly increased risk of lymph node metastasis (incidence 57.6% and 72.7%, odds ratio 33.8 and 49.9, respectively, P50% myometrial tumor invasion, cervical stromal invasion, and adnexal involvement: incidence range 30.4–37.9%, odds ratio range 3.80–7.03). Deep and extensive of LVSI patterns were both significantly correlated to distant recurrence (P<0.001). Among women who received postoperative chemotherapy, deep and extensive LVSI patterns did not have increased risks for distant recurrence compared to no LVSI (P=0.47 and 0.32, respectively). Among women who received postoperative radiotherapy, the depth of LVSI was significantly associated with recurrence outside the radiated field (P=0.02). Depth and extent of LVSI are important predictors for lymph node metastasis and distant recurrence in endometrial cancer. |
| Related Links | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7526048/pdf |
| Ending Page | 676 |
| Page Count | 8 |
| Starting Page | 669 |
| e-ISSN | 10969098 |
| DOI | 10.1002/jso.24049 |
| Journal | Journal of Surgical Oncology |
| Issue Number | 6 |
| Volume Number | 112 |
| Language | English |
| Publisher | Wiley-Blackwell |
| Publisher Date | 2015-09-22 |
| Access Restriction | Open |
| Subject Keyword | Journal: Journal of Surgical Oncology Obstetrics and Gynecology Endometrial Cancer Lymphovascular Space Invasion Lymph Node Metastasis |
| Content Type | Text |
| Resource Type | Article |
