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Analysis of theDPC4Gene in Gastric Carcinoma
| Content Provider | Scilit |
|---|---|
| Author | Nishizuka, Satoshi Tamura, Gen Maesawa, Chihaya Sakata, Ken Suzuki, Yasushi Iwaya, Takeshi Terashima, Masanori Saito, Kazuyoshi Satodate, Ryoichi |
| Copyright Year | 1997 |
| Description | Journal: Japanese Journal of Cancer Research Allelic loss on chromosome 18q is involved in the progression of gastric carcinoma. Recently, DPC4 (deleted in pancreatic carcinoma, locus 4), a candidate tumor suppressor gene, has been localized at 18q21.1. This gene is inactivated in nearly one half of pancreatic carcinomas. We tested for DPC4 gene mutations and allelic status at 18q21 in 30 primary gastric carcinomas and 5 gastric carcinoma cell lines. Polymerase chain reaction single‐strand conformation polymorphism and sequencing analyses revealed no DPC4 mutations in any of the primary tumors or cell lines. Homozygous deletion ofDPC4 was observed in only 1 (MKN‐45) of the 5 (20%) cell lines. This suggests that the target gene for loss on 18q is not DPC4. The true tumor suppressor gene, encoded near DPC4, has yet to be identified. |
| Related Links | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5921423/pdf http://onlinelibrary.wiley.com/doi/10.1111/j.1349-7006.1997.tb00385.x/pdf |
| Ending Page | 339 |
| Page Count | 5 |
| Starting Page | 335 |
| ISSN | 09105050 |
| DOI | 10.1111/j.1349-7006.1997.tb00385.x |
| Journal | Japanese Journal of Cancer Research |
| Issue Number | 4 |
| Volume Number | 88 |
| Language | English |
| Publisher | Wiley-Blackwell |
| Publisher Date | 1997-04-01 |
| Access Restriction | Open |
| Subject Keyword | Journal: Japanese Journal of Cancer Research Chromosome 18q Tumor Suppressor Gene Gastric Carcinoma |
| Content Type | Text |
| Resource Type | Article |
| Subject | Cancer Research Oncology |
