NDLI: Dual inhibition of ras and bcr-abl signalling pathways in chronic myeloid leukaemia: a phase I/II study in patients in complete haematological remission

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Dual inhibition of ras and bcr-abl signalling pathways in chronic myeloid leukaemia: a phase I/II study in patients in complete haematological remission

Content Provider	Scilit
Author	Pavlu, Jiri Andreasson, Catharina Chuah, Charles Kaeda, Jaspal Goldman, John M. Apperley, Jane F. Marin, David
Copyright Year	2007
Description	Journal: British Journal of Haematology Zoledronic acid inhibits the prenylation of ras-related proteins downstream of bcr-abl and preclinical studies have shown augmentation of the inhibitory effects of imatinib in BCR-ABL expressing cells. A Phase I/II study was designed to assess the safety and efficacy of the addition of zoledronic acid to imatinib in patients with chronic myeloid leukaemia (CML) with a suboptimal response to imatinib alone. Ten patients with CML who had been treated with imatinib for at least 2 years and had achieved and maintained a complete haematological response were included. Zoledronic acid was administered intravenously on one occasion every 28 d. The initial dose of 4 mg was given for three consecutive months; in the absence of significant toxicity and/or response the dose was escalated to 8 mg for an additional 3 months. Efficacy was assessed by serial monitoring of blood levels of BCR-ABL transcripts and bone marrow cytogenetics. Addition of zoledronic acid to imatinib caused no haematological toxicity. There were no grade III or IV non-haematological adverse effects. Grade I fatigue, hypocalcaemia and fever were common side effects. No responses were demonstrated after 6 months on the combination.
Ending Page	428
Starting Page	423
ISSN	2573508X
e-ISSN	13652141
DOI	10.1111/j.1365-2141.2007.06578.x
Journal	British Journal of Haematology
Issue Number	5
Volume Number	137
Language	English
Publisher	Wiley-Blackwell
Publisher Date	2007-06-01
Access Restriction	Open
Subject Keyword	Journal: British Journal of Haematology Chronic Myeloid Leukaemia
Content Type	Text
Resource Type	Article

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