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Predictive value of early serum β-hCG levels after single blastocyst transfer
| Content Provider | Scilit |
|---|---|
| Author | Ochsenkühn, Robert Arzberger, Andrea von Schönfeldt, Viktoria Engel, Jutta Thaler, Christian J. Noss, Ulrich |
| Copyright Year | 2009 |
| Description | Journal: Acta Obstetricia et Gynecologica Scandinavica Objective. Analysis of serum β-human chorionic gonadotropin (β-hCG) levels on standardized days after oocyte retrieval (OR) following single blastocyst transfer to predict pregnancy outcome after assisted reproductive technology. Design. Retrospective study. Setting. Private fertility center. Population. A total of 230 women with an intact intrauterine pregnancy 21 days after OR and a vital term delivery (n = 191) or a miscarriage (< 10+0 gestational weeks) (n = 39) in the course of the pregnancy following single blastocyst transfer between 1999 and 2008. Methods. Blood was sampled 11, 14 and partly 21 days after OR. The serum concentration of total β-hCG was measured by an automated quantitative immunoassay. Receiver operating characteristic curves were generated to calculate sensitivity and specificity. Main outcome measures. A total of 509 β-hCG measurements. Results. The mean β-hCG concentrations on days 11, 14 and 21 after OR were significantly lower in the group of patients with a miscarriage compared to the group with a term delivery (p = 0.02, < 0.001 and < 0.001 respectively). With the cut-off values of 15 mIU/mL, 80 mIU/mL and 1500 mIU/mL on days 11, 14 and 21, the positive predictive value was 89%, 93% and 92%. The negative predictive value was 28%, 40% and 54%. Conclusions. The predictive value of a single β-hCG measurement for pregnancy outcome after single blastocyst transfer increases between days 11 and 21 after OR. A single β-hCG measurement on day 14 may balance the accuracy of prediction and the necessity of an early reassuring test. |
| Ending Page | 1388 |
| Starting Page | 1382 |
| ISSN | 00221295 |
| e-ISSN | 16000412 |
| DOI | 10.3109/00016340903322743 |
| Journal | Acta Obstetricia et Gynecologica Scandinavica |
| Issue Number | 12 |
| Volume Number | 88 |
| Language | English |
| Publisher | Wiley-Blackwell |
| Publisher Date | 2009-12-01 |
| Access Restriction | Open |
| Subject Keyword | Journal: Acta Obstetricia et Gynecologica Scandinavica Reproductive Biology Pregnancy Outcome Single Blastocyst Blastocyst Transfer |
| Content Type | Text |
| Resource Type | Article |
| Subject | Obstetrics and Gynecology |
