NDLI: The role of CXCR7 on the adhesion, proliferation and angiogenesis of endothelial progenitor cells

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The role of CXCR7 on the adhesion, proliferation and angiogenesis of endothelial progenitor cells

Content Provider	Scilit
Author	Dai, Xiaozhen Tan, Yi Cai, Shao Xi Xiong, Xin Wang, Lingqiao Ye, Qun Fang Yan, Xiaoqing Ma, Kaiwang Cai, Lu
Copyright Year	2011
Description	Journal: Journal of Cellular and Molecular Medicine Previous studies confirmed that stromal cell-derived factor 1 (SDF-1) was a principal regulator of retention, migration and mobilization of haematopoietic stem cells and endothelial progenitor cells (EPCs) during steady-state homeostasis and injury. CXC chemokine receptor 4 (CXCR4) has been considered as the unique receptor of SDF-1 and as the only mediator of SDF-1-induced biological effects for many years. However, recent studies found that SDF-1 could bind to not only CXCR4 but also CXC chemokine receptor 7 (CXCR7). The evidence that SDF-1 binds to the CXCR7 raises a concern how to distinguish the potential contribution of the SDF-1/CXCR7 pathway from SDF-1/CXCR4 pathway in all the processes that were previously attributed to SDF-1/CXCR4. In this study, the role of CXCR7 in EPCs was investigated in vitro. RT-PCR, Western blot and flow cytometry assay demonstrate that both CXCR4 and CXCR7 were expressed highly in EPCs. The adhesion of EPCs induced by SDF-1 was inhibited by blocking either CXCR4 or CXCR7 with their antibodies or antagonists. SDF-1 regulated the migration of EPCs via CXCR4 but not CXCR7. However, the transendothelial migration of EPCs was inhibited by either blocking of CXCR4 or CXCR7. Both CXCR7 and CXCR4 are essential for the tube formation of EPCs induced by SDF-1. These results suggested that both CXCR7 and CXCR4 are important for EPCs in response to SDF-1, indicating that CXCR7 may be another potential target molecule for angiogenesis-dependent diseases.
Related Links	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4373330/pdf http://onlinelibrary.wiley.com/doi/10.1111/j.1582-4934.2011.01301.x/pdf
Ending Page	1309
Page Count	11
Starting Page	1299
e-ISSN	15824934
DOI	10.1111/j.1582-4934.2011.01301.x
Journal	Journal of Cellular and Molecular Medicine
Issue Number	6
Volume Number	15
Language	English
Publisher	Wiley-Blackwell
Publisher Date	2011-05-30
Access Restriction	Open
Subject Keyword	Journal: Journal of Cellular and Molecular Medicine Biochemistry and Molecular Biology Cxc Chemokine Receptor 7 Stromal Cell‐derived Factor 1 Endothelial Progenitor Cells Cxc Chemokine Receptor 4
Content Type	Text
Resource Type	Article

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