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Palladium‐Catalyzed Dearomative syn ‐1,4‐Oxyamination
| Content Provider | Scilit |
|---|---|
| Author | Tang, Conghui Okumura, Mikiko Deng, Hejun Sarlah, David |
| Copyright Year | 2019 |
| Description | Journal: Angewandte Chemie International Edition A palladium‐catalyzed dearomative syn‐1,4‐oxyamination protocol using non‐activated arenes has been developed. This one‐pot procedure utilizes arenophile chemistry, and the corresponding para‐cycloadducts are treated with oxygen nucleophiles via formal allylic substitution, providing direct access to syn‐1,4‐oxyaminated products. The reaction conditions permit a range of arenes, as well as different O‐nucleophiles, such as oximes and benzyl alcohols. Moreover, this process was established in an asymmetric fashion, delivering products with high enantioselectivity. The dearomatized products are amenable to a multitude of further derivatizations ranging from olefin chemistry to C−H activation, giving rise to a diverse set of new functionalities. Overall, this dearomative functionalization offers rapid and controlled formation of molecular complexity, enabling straightforward access to functionalized small molecules from simple and readily available arenes. |
| Related Links | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6803049/pdf |
| Ending Page | 15766 |
| Page Count | 5 |
| Starting Page | 15762 |
| ISSN | 14337851 |
| e-ISSN | 15213773 |
| DOI | 10.1002/anie.201909838 |
| Journal | Angewandte Chemie International Edition |
| Issue Number | 44 |
| Volume Number | 58 |
| Language | English |
| Publisher | Wiley-Blackwell |
| Publisher Date | 2019-09-03 |
| Access Restriction | Open |
| Subject Keyword | Journal: Angewandte Chemie International Edition Organic Chemistry |
| Content Type | Text |
| Resource Type | Article |
| Subject | Chemistry Catalysis |
