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Entorhinal and transentorhinal atrophy in mild cognitive impairment using longitudinal diffeomorphometry
| Content Provider | Scilit |
|---|---|
| Author | Tward, Daniel J. Sicat, Chelsea S. Brown, Timothy Bakker, Arnold Gallagher, Michela Albert, Marilyn Miller, Michael |
| Copyright Year | 2017 |
| Description | Journal: Alzheimer's & Dementia: Diagnosis, Assessment & Disease Monitoring Autopsy findings have shown the entorhinal cortex and transentorhinal cortex are among the earliest sites of accumulation of pathology in patients developing Alzheimer's disease. Here, we study this region in subjects with mild cognitive impairment (n = 36) and in control subjects (n = 16). The cortical areas are manually segmented, and local volume and shape changes are quantified using diffeomorphometry, including a novel mapping procedure that reduces variability in anatomic definitions over time. We find significant thickness and volume changes localized to the transentorhinal cortex through high field strength atlasing. This demonstrates that in vivo neuroimaging biomarkers can detect these early changes among subjects with mild cognitive impairment. |
| Related Links | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5608074/pdf |
| Ending Page | 50 |
| Page Count | 10 |
| Starting Page | 41 |
| ISSN | 23528729 |
| e-ISSN | 23528729 |
| DOI | 10.1016/j.dadm.2017.07.005 |
| Journal | Alzheimer's & Dementia: Diagnosis, Assessment & Disease Monitoring |
| Issue Number | 1 |
| Volume Number | 9 |
| Language | English |
| Publisher | Wiley-Blackwell |
| Publisher Date | 2017-01-01 |
| Access Restriction | Open |
| Subject Keyword | Journal: Alzheimer's & Dementia: Diagnosis, Assessment & Disease Monitoring Entorhinal Cortex Mild Cognitive Impairment Diffeomorphometry Longitudinal Analysis |
| Content Type | Text |
| Resource Type | Article |
| Subject | Neurology (clinical) Psychiatry and Mental Health |
