NDLI: Insulin-stimulated protein synthesis in adipocytes. Enhanced rate of initiation associated with increased phosphorylation of ribosomal protein S6

Please wait, while we are loading the content...

Insulin-stimulated protein synthesis in adipocytes. Enhanced rate of initiation associated with increased phosphorylation of ribosomal protein S6

Content Provider	Scilit
Author	Hansson, Anders Ingelman-Sundberg, Magnus
Copyright Year	1985
Description	Journal: Journal of Biological Inorganic Chemistry The mechanisms of insulin stimulation of protein synthesis in adipocytes are presently unknown. Addition of 10 nM insulin to isolated rat adipocytes caused a 1.5-2.5-fold increase in the protein synthetic rate and a corresponding increase in nascent chain level, indicating that the effect of insulin on protein synthesis in adipocytes is mediated by a stimulation of ribosomal initiation. The effect on protein synthesis exhibited a lag time of 6-8 min after insulin addition. A similar time dependence was also observed for the insulin-induced phosphorylation of ribosomal protein S6. This supports the proposal that these two phenomena are causally linked.
Related Links	http://onlinelibrary.wiley.com/doi/10.1111/j.1432-1033.1985.tb09073.x/pdf
ISSN	09498257
e-ISSN	14321327
DOI	10.1111/j.1432-1033.1985.tb09073.x
Journal	Journal of Biological Inorganic Chemistry
Issue Number	1
Volume Number	151
Language	English
Publisher	Wiley-Blackwell
Publisher Date	1985-08-01
Access Restriction	Open
Subject Keyword	Journal: Journal of Biological Inorganic Chemistry Biochemistry and Molecular Biology Protein Synthesis Ribosomal Protein S6
Content Type	Text
Resource Type	Article
Subject	Biochemistry Inorganic Chemistry

Sl.	Authority	Responsibilities	Communication Details
1	Ministry of Education (GoI), Department of Higher Education	Sanctioning Authority	https://www.education.gov.in/ict-initiatives
2	Indian Institute of Technology Kharagpur	Host Institute of the Project: The host institute of the project is responsible for providing infrastructure support and hosting the project	https://www.iitkgp.ac.in
3	National Digital Library of India Office, Indian Institute of Technology Kharagpur	The administrative and infrastructural headquarters of the project	Dr. B. Sutradhar bsutra@ndl.gov.in
4	Project PI / Joint PI	Principal Investigator and Joint Principal Investigators of the project	Dr. B. Sutradhar bsutra@ndl.gov.in Prof. Saswat Chakrabarti will be added soon
5	Website/Portal (Helpdesk)	Queries regarding NDLI and its services	support@ndl.gov.in
6	Contents and Copyright Issues	Queries related to content curation and copyright issues	content@ndl.gov.in
7	National Digital Library of India Club (NDLI Club)	Queries related to NDLI Club formation, support, user awareness program, seminar/symposium, collaboration, social media, promotion, and outreach	clubsupport@ndl.gov.in
8	Digital Preservation Centre (DPC)	Assistance with digitizing and archiving copyright-free printed books	dpc@ndl.gov.in
9	IDR Setup or Support	Queries related to establishment and support of Institutional Digital Repository (IDR) and IDR workshops	idr@ndl.gov.in