Serum angiotensin converting enzyme activity and response to angiotensin I in horses

Content Provider	Scilit
Author	Tillman, L. G. Moore, J. N.
Copyright Year	1989
Description	Journal: Equine veterinary journal The activity of serum angiotensin converting enzyme (ACE) for healthy horses was 64 +/- 13 mUnits/ml. In vitro, equine serum ACE was sensitive to the following inhibitors (IC50): enalapril (570 nM or 215 ng/ml), captopril (190 nM or 41.3 ng/ml), and enalaprilat (6 nM or 2.1 ng/ml). The intravenous (i.v.) administration of angiotensin I to six healthy horses produced a dose proportional pressor response. The maximal increase in mean arterial pressure over baseline values was 65.6 mmHg at angiotensin I doses of 500 ng/kg bodyweight (bwt). The attenuation of this response to angiotensin I was further demonstrated in a single horse by the prior administration of enalaprilat at an i.v. dose of 8.71 micrograms/kg bwt.
Related Links	http://onlinelibrary.wiley.com/doi/10.1111/j.2042-3306.1989.tb05662.x/pdf
Ending Page	83
Page Count	4
Starting Page	80
e-ISSN	20423306
DOI	10.1111/j.2042-3306.1989.tb05662.x
Journal	Equine veterinary journal
Issue Number	7
Volume Number	21
Language	English
Publisher	Wiley-Blackwell
Publisher Date	1989-06-07
Access Restriction	Open
Subject Keyword	Journal: Equine veterinary journal Angiotensin Converting Enzyme Serum Angiotensin Converting Response To Angiotensin
Content Type	Text
Resource Type	Article