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Association of Alcohol Dehydrogenase Genes with Alcohol-Related Phenotypes in a Native American Community Sample
| Content Provider | Scilit |
|---|---|
| Author | Gizer, Ian R. Edenberg, Howard J. Gilder, David A. Wilhelmsen, Kirk C. Ehlers, Cindy L. |
| Copyright Year | 2011 |
| Description | Journal: Alcoholism: Clinical and Experimental Research Background: Previous linkage studies, including a study of the Native American population described in the present report, have provided evidence for linkage of alcohol dependence and related traits to chromosome 4q near a cluster of alcohol dehydrogenase (ADH) genes, which encode enzymes of alcohol metabolism. Methods: The present study tested for associations between alcohol dependence and related traits and 22 single‐nucleotide polymorphisms (SNPs) spanning the 7 ADH genes. Participants included 586 adult men and women recruited from 8 contiguous Native American reservations. A structured interview was used to assess DSM‐III‐R alcohol dependence criteria as well as a set of severe alcohol misuse symptoms and alcohol withdrawal symptoms. Results: No evidence for association with the alcohol dependence diagnosis was observed, but an SNP in exon 9 of ADH1B (rs2066702; ADH1B*3) and an SNP at the 5′ end of ADH4 (rs3762894) showed significant evidence of association with the presence of withdrawal symptoms (p = 0.0018 and 0.0012, respectively). Further, a haplotype analysis of these 2 SNPs suggested that the haplotypes containing either of the minor alleles were protective against alcohol withdrawal relative to the ancestral haplotype (p = 0.000006). Conclusions: These results suggest that variants in the ADH1B and ADH4 genes may be protective against the development of some symptoms associated with alcohol dependence. |
| Related Links | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3197765/pdf |
| Ending Page | 2018 |
| Page Count | 11 |
| Starting Page | 2008 |
| e-ISSN | 15300277 |
| DOI | 10.1111/j.1530-0277.2011.01552.x |
| Journal | Alcoholism: Clinical and Experimental Research |
| Issue Number | 11 |
| Volume Number | 35 |
| Language | English |
| Publisher | Wiley-Blackwell |
| Publisher Date | 2011-06-02 |
| Access Restriction | Open |
| Subject Keyword | Journal: Alcoholism: Clinical and Experimental Research Substance Abuse Alcohol Dehydrogenase Alcohol Dependence Alcohol Withdrawal Genetic Association Candidate Gene Analysis |
| Content Type | Text |
| Resource Type | Article |
