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High temporal resolution dynamic MRI and arterial input function for assessment of GFR in pediatric subjects
| Content Provider | Scilit |
|---|---|
| Author | Yoruk, Umit Saranathan, Manojkumar Loening, Andreas M. Hargreaves, Brian A. Vasanawala, Shreyas S. |
| Copyright Year | 2016 |
| Description | Journal: Magnetic Resonance in Medicine To introduce a respiratory-gated high-spatiotemporal-resolution dynamic-contrast-enhanced MRI technique and a high-temporal-resolution aortic input function (HTR-AIF) estimation method for glomerular filtration rate (GFR) assessment in children. A high-spatiotemporal-resolution DCE-MRI method with view-shared reconstruction was modified to incorporate respiratory gating, and an AIF estimation method that uses a fraction of the k-space data from each respiratory period was developed (HTR-AIF). The method was validated using realistic digital phantom simulations and demonstrated on clinical subjects. The GFR estimates using HTR-AIF were compared with estimates obtained by using an AIF derived directly from the view-shared images. Digital phantom simulations showed that using the HTR-AIF technique gives more accurate AIF estimates (RMSE = 0.0932) compared with the existing estimation method (RMSE = 0.2059) that used view-sharing (VS). For simulated GFR > 27 mL/min, GFR estimation error was between 32% and 17% using view-shared AIF, whereas estimation error was less than 10% using HTR-AIF. In all clinical subjects, the HTR-AIF method resulted in higher GFR estimations than the view-shared method. The HTR-AIF method improves the accuracy of both the AIF and GFR estimates derived from the respiratory-gated acquisitions, and makes GFR estimation feasible in free-breathing pediatric subjects. |
| Related Links | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4636486/pdf |
| Ending Page | 1311 |
| Page Count | 11 |
| Starting Page | 1301 |
| e-ISSN | 15222594 |
| DOI | 10.1002/mrm.25731 |
| Journal | Magnetic Resonance in Medicine |
| Issue Number | 3 |
| Volume Number | 75 |
| Language | English |
| Publisher | Wiley-Blackwell |
| Publisher Date | 2016-03-01 |
| Access Restriction | Open |
| Subject Keyword | Journal: Magnetic Resonance in Medicine Radiology, Nuclear Medicine and Imaging Arterial Input Function Estimation Dynamic Contrast Enhancement Glomerular Filtration Rate Estimation High Spatiotemporal Resolution Dynamic Imaging |
| Content Type | Text |
| Resource Type | Article |
