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Effects of the anti-CD2 mAb OX34 on in vivo proliferation.
| Content Provider | Scilit |
|---|---|
| Author | Hoffmann, J. C. Herklotz, C. Zeitz, M. Bayer, B. Zeidler, H. Westermann, J. |
| Copyright Year | 1998 |
| Description | Journal: Annals of the New York Academy of Sciences In vitro studies indicate that CD2 plays an important role in the intestinal immune system with regard to T cell proliferation and T helper 2 differentiation. We asked whether anti-CD2 mAb induces T-cell proliferation in vivo. Rats received anti-CD2 mAb OX34 or control mAb over 3 days. Before exsanguination BrdU was injected. Lymphatic organs were processed for two-color immunohistology. OX34 depleted CD4+ but not CD8+ T cells in all organs. Remaining CD4+ T cells proliferated in the periarteriolar lymphocyte sheets. Surprisingly, OX34 led to strong proliferation of splenocytes in the red pulp. These cells were negative for markers of T cells, B cells, NK cells, macrophages, and myeloid cells. Taken together, the anti-CD2 mAb OX34 leads to proliferation of an as-yet-unidentified cell type in the red pulp of the spleen but not to proliferation of T cells. |
| Related Links | http://onlinelibrary.wiley.com/doi/10.1111/j.1749-6632.1998.tb11132.x/pdf |
| Ending Page | 218 |
| Page Count | 3 |
| Starting Page | 216 |
| e-ISSN | 17496632 |
| DOI | 10.1111/j.1749-6632.1998.tb11132.x |
| Journal | Annals of the New York Academy of Sciences |
| Issue Number | 1 |
| Volume Number | 859 |
| Language | English |
| Publisher | Wiley-Blackwell |
| Publisher Date | 1998-11-01 |
| Access Restriction | Open |
| Subject Keyword | Journal: Annals of the New York Academy of Sciences Biochemistry and Molecular Biology |
| Content Type | Text |
| Resource Type | Article |
