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Effect of neuromuscular electrical stimulation frequency on muscles of the tongue
| Content Provider | Scilit |
|---|---|
| Author | Kletzien, Heidi Russell, John A. Leverson, Glen Connor, Nadine P. |
| Copyright Year | 2018 |
| Description | Journal: Muscle & Nerve Introduction: Neuromuscular electrical stimulation (NMES) for the treatment of swallowing disorders is delivered at a variety of stimulation frequencies. We examined the effects of stimulation frequency on tongue muscle plasticity in an aging rat model. Methods: Eighty‐six young, middle‐aged, and old rats were assigned to either bilateral hypoglossal nerve stimulation at 10 or 100 Hz (5 days/wk, 8 wks), sham, or no implantation conditions. Muscle contractile properties and myosin heavy chain (MyHC) composition were determined for hyoglossus (HG) and styloglossus (SG) muscles. Results: Eight‐weeks of 100 Hz stimulation resulted in the greatest changes in muscle contractile function with significantly longer contraction and half‐decay times, greatest reduction in fatigue, and a transition toward slowly contracting, fatigue‐resistant MyHC isoforms. Discussion: NMES at 100 Hz induced considerable changes in contractile and phenotypic profiles of HG and SG muscles, suggesting higher frequency NMES may yield a greater therapeutic effect. This article is protected by copyright. All rights reserved. |
| Related Links | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6160334/pdf |
| Ending Page | 448 |
| Page Count | 8 |
| Starting Page | 441 |
| e-ISSN | 10974598 |
| DOI | 10.1002/mus.26173 |
| Journal | Muscle & Nerve |
| Issue Number | 3 |
| Volume Number | 58 |
| Language | English |
| Publisher | Wiley-Blackwell |
| Publisher Date | 2018-09-01 |
| Access Restriction | Open |
| Subject Keyword | Journal: Muscle & Nerve Swallowing Disorders Neuromuscular Electrical Stimulation Stimulation Frequency Tongue Musculature Rodent Model |
| Content Type | Text |
| Resource Type | Article |
